Actively Recruiting

Age: 16Years +
All Genders
ID07351838

Prognosis and Risk Stratification in Non-dilated Left Ventricular Cardiomyopathy: Cardiac MRI Insights for Better Outcomes

Led by Chinese Academy of Medical Sciences, Fuwai Hospital · Updated on 2026-01-21

1000

Participants Needed

1

Research Sites

104 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are examining non-dilated left ventricular cardiomyopathy (NDLVC), a subtype of heart muscle disease characterized by abnormalities without enlargement of the left ventricle. This retrospective observational study aims to explore how cardiac magnetic resonance (CMR) findings relate to long-term outcomes and to identify key risk factors for serious heart-related events in patients with NDLVC. The purpose is to develop a CMR-based risk stratification method to help guide clinical decisions and improve patient care. Patients diagnosed with NDLVC who underwent CMR at the study institution during the specified period will be enrolled retrospectively. Key CMR parameters analyzed include left ventricular ejection fraction (LVEF), late gadolinium enhancement (LGE) patterns, myocardial strain, and the extent of myocardial fibrosis or fatty replacement. The primary outcome measured is a combination of major adverse cardiac events, such as death, heart transplantation, or left ventricular assist device implantation. Participant data will be collected from medical records and CMR databases. The study will assess these imaging features against patient outcomes over a follow-up period of up to 100 months. By analyzing these factors, the research aims to clarify the link between specific CMR characteristics and prognosis in NDLVC. This will support better risk assessment and improve clinical management strategies for affected patients.

CONDITIONS

Brief Title

Cardiac Magnetic Resonance for Risk Stratification in Non-dilated Left Ventricular Cardiomyopathy

Who Can Participate

Age: 16Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 16 years or older
  • Indexed left ventricular end-diastolic volume below 96 mL/m2 for females and below 105 mL/m2 for males at baseline cardiac magnetic resonance
  • Left ventricular ejection fraction under 50% and/or presence of non-ischemic left ventricular scar or fatty replacement at baseline cardiac magnetic resonance
Not Eligible

You will not qualify if you...

  • Lack of enhanced cardiac magnetic resonance images due to contraindications like severe kidney disease
  • Presence of ischemic heart disease defined by major coronary artery stenosis over 50%, ischemic late gadolinium enhancement pattern, or prior coronary revascularization
  • Moderate to severe valvular heart diseases, congenital heart diseases, or uncontrolled hypertension
  • Systemic rheumatologic diseases or sarcoidosis
  • Meeting diagnostic criteria for other cardiomyopathies according to European Society of Cardiology definitions

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Baseline

Participants undergo cardiac magnetic resonance imaging to assess heart function and structure.

1 visit (in-person)

Long-term Monitoring

Duration - Up to 100 months

Participants are observed over time to assess the occurrence of major cardiac events and overall heart health.

Periodic follow-up visits depending on clinical availability

Trial Site Locations

Total: 1 location

1

Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital

Beijing, China, 100037

Actively Recruiting

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Research Team

L

Lu Minjie PHD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

CarDiac magnEtic Resonance for prophylactic Implantable cardioVerter defibrillAtor ThErapy in Non-Dilated Left Ventricular Cardiomyopathy: a sub-study from the DERIVATE registry.

Isabella Leo, Santo Dellegrottaglie, Alessandra Scatteia...

https://pubmed.ncbi.nlm.nih.gov/39899463

Magnetic Resonance Imaging Characterization and Clinical Outcomes of Dilated and Arrhythmogenic Left Ventricular Cardiomyopathies.

Matteo Castrichini, Antonio De Luca, Giulia De Angelis...

https://pubmed.ncbi.nlm.nih.gov/38719365