Advanced Cardiac MRI Stress-Perfusion Study in Adults with Fontan Circulation after Total Cavo-Pulmonary Connection Surgery

What this Trial Is About

Researchers are studying adults with univentricular heart UVH, a serious congenital heart condition, to improve early detection of heart function decline and microvascular problems before symptoms worsen. The study aims to better inform treatment, monitoring, and follow-up using advanced cardiovascular magnetic resonance CMR imaging, which is a non-invasive method that provides detailed heart anatomy and function without radiation. The goal is to help young adults with UVH by potentially reducing hospital stays and improving health outcomes. The study uses a 1.5 Tesla Siemens magnet for CMR imaging while patients lie down. Imaging includes various scans and a blood test before the procedure. Participants receive an intravenous contrast agent and undergo stress testing with adenosine or regadenoson to evaluate heart blood flow and function. The imaging captures detailed heart motion and tissue characteristics under stress and rest conditions. Participants avoid caffeine for 24 hours before imaging. During the study, participants undergo imaging and blood tests to assess heart function, venous pressure, and microvascular health. Researchers will measure outcomes such as the detection of microvascular dysfunction and tissue characteristics over about one year. The study collects detailed data to understand heart behavior in these patients, aiming to support early treatment decisions and improve care management.

Cardiac Magnetic Resonance Stress-perfusion Study in Patinets with Fontan Circulation