Actively Recruiting
Cardiac MRI-guided Deferiprone Therapy for Acute Myocardial Infarction Patients
Led by Rohan Dharmakumar · Updated on 2026-04-08
89
Participants Needed
1
Research Sites
355 weeks
Total Duration
On this page
Sponsors
R
Rohan Dharmakumar
Lead Sponsor
M
Minneapolis Heart Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this randomized, controlled pilot study is to determine the efficacy of Deferiprone to reduce the amount of free iron inside the hemorrhagic zone of myocardial infarction among hemorrhagic myocardial infarction patients.
CONDITIONS
Official Title
Cardiac MRI-guided Deferiprone Therapy for Acute Myocardial Infarction Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-79 years
- Index Anterior wall STEMI
- Emergency coronary angiogram with primary PCI
You will not qualify if you...
- Prior history of MI, PCI, or coronary artery bypass graft within previous 1 year
- History of left ventricular ejection fraction less than 40%
- Use of investigational drugs or devices 30 days prior to randomization
- Known allergy or contraindication to gadolinium or contrast agents
- Estimated glomerular filtration rate less than 30 ml/kg/min
- Any contraindication to cardiac MRI such as metal implants
- Women who are pregnant or breastfeeding; women of reproductive potential must have negative pregnancy test prior to randomization
- Body weight greater than 140 kg (309 lbs.)
- Absolute neutrophil count less than 1.5 k/cumm
- History of chronic liver disease
- Elevated liver enzymes (both ALT and AST) more than twice the upper normal limit
- Patients with iron storage diseases or already treated with iron chelators
- Any clinically significant abnormality that would preclude safe study completion or confound expected benefit
- Life expectancy less than 1 year due to non-cardiac conditions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IU Methodist Hospital (IUHealth)
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
C
Clinical Research Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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