Actively Recruiting
Cardiac RadiothErapy For hEart faiLure
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2025-12-01
40
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Preliminary data suggests that patients suffering from advanced refractory heart failure (HF) could benefit from single low dose whole heart external beam radiotherapy (EBRT). Objective: To explore in our center the efficacy of administering a EBRT treatment of 5Gy to the whole heart in patients with advanced and refractory HF. The hypothesis is that 5Gy EBRT to the whole heart can improve the left ventricular ejection fraction (LVEF) of these patients by a clinically relevant 5%. Main study endpoints: The primary aim is to explore the efficacy of EBRT treatment for advanced refractory HF. Secondary endpoints include an assessment of safety, overall survival, hospital admissions, late toxicity, quality of life and the effect of the treatment on other heart function indicators (left ventricular volumes, NT-proBNP, Troponine, High sensitive CRP).
CONDITIONS
Official Title
Cardiac RadiothErapy For hEart faiLure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient 18 years or older
- Advanced refractory heart failure NYHA class II, III, or IV
- Stable heart failure for the last 6 months with maximal guideline-directed therapy
- Diagnosis of ischemic or dilated cardiomyopathy
- Left ventricular ejection fraction at baseline 35% or less
- Ability to give written informed consent and willingness to return for follow-up
You will not qualify if you...
- Eligible or being considered for heart transplantation
- Pregnancy or breastfeeding
- Previous radiotherapy involving the heart
- Any condition deemed a contraindication by the investigators
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UZ Leuven
Leuven, Belgium, 3000
Actively Recruiting
Research Team
P
Patrick Berkovic, MD PhD
CONTACT
B
Bert Vandenberk, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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