Exploring 5Gy Whole Heart Radiotherapy Treatment for Advanced Refractory Heart Failure Evaluating Its Effect on Heart Function and Patient Outcomes

What this Trial Is About

Researchers are evaluating the use of a single low dose of whole heart external beam radiotherapy EBRT for patients with advanced refractory heart failure HF. The study aims to explore whether a 5 Gy dose to the whole heart can improve heart function, specifically the left ventricular ejection fraction LVEF, by a clinically relevant 5%. The research also looks at safety, survival, hospital admissions, quality of life, and other heart function markers in people with ischemic or dilated cardiomyopathy. Participants will receive a one-time radiation treatment of 5 Gray to the whole heart using photon energies of 6 Megavoltage with advanced techniques like intensity modulated radiotherapy IMRT or volumetric modulated arc therapy VMAT. This treatment can be done as an inpatient or outpatient procedure. The study follows patients over time to assess changes and effects of this treatment on heart function and overall health. During the study, researchers will measure heart function changes at baseline, 6 weeks, 12 weeks, and 6 months after treatment. They will monitor acute and late toxicity, mortality, hospitalizations related to heart failure, quality of life using SF-36 and MLWHF questionnaires, and several blood markers including NT-proBNP, troponin, and C-reactive protein. The study will last up to 6 months after treatment to observe these outcomes and safety aspects.

Cardiac RadiothErapy For hEart faiLure