Actively Recruiting
Led by Instituto Nacional de Cardiologia de Laranjeiras · Updated on 2026-03-27
50
Participants Needed
1
Research Sites
N/A
Total Duration
I
Instituto Nacional de Cardiologia de Laranjeiras
Lead Sponsor
R
Rio de Janeiro State University
Collaborating Sponsor
This research aims to evaluate the effects of a cardiovascular rehabilitation program on patients with coronary artery disease (CAD) aged 40 to 70 years. The study compares these patients with a reference group of healthy individuals matched by age and physical activity level. The purpose is to assess changes in artery thickness, endothelial function, inflammation, and metabolic biomarkers related to CAD. Participants include 28 CAD patients and 22 healthy controls, with evaluations conducted before and after a 12-week exercise intervention. The intervention involves a supervised exercise program combining aerobic, resistance, and flexibility training, conducted three times per week for 12 weeks. Each session lasts 60 minutes, with aerobic exercises performed at moderate intensity on a treadmill or stationary bike, and resistance exercises targeting major muscle groups. Healthy controls do not receive any intervention and serve as a comparison group. Assessments take place at two visits: the first includes carotid artery ultrasound and cardiopulmonary exercise testing, while the second assesses vascular function and collects blood samples before and after moderate aerobic exercise. Participants attend two assessment visits at baseline and after the 12-week program, with at least 72 hours between visits. During visits, medical history, artery thickness, vascular function, and blood biomarkers related to inflammation, endothelial injury, and kynurenine pathway metabolites are measured. Exercise performance and oxygen consumption are also evaluated. The study monitors safety and adherence through standardized procedures and controlled environmental conditions. Total participation spans the 12-week intervention and follow-up assessments.
CONDITIONS
Cardiac Rehabilitation and Coronary Artery Disease
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - 12 weeks
Participants in the exercise training group undergo a 12-week supervised multimodal exercise program including aerobic, resistance, and flexibility exercises, performed in 3 weekly sessions lasting 60 minutes each.
3 exercise sessions per week (in-person)
Duration - 2 visits over the study period
Participants attend two assessment visits at baseline and after the 12-week intervention to evaluate carotid intima-media thickness, cardiopulmonary exercise testing, blood biomarkers, vascular function, and maximal oxygen consumption.
2 visits (in-person) separated by at least 72 hours
Total: 1 location
1
Rio de Janeiro State University
Rio de Janeiro, Rio de Janeiro, Brazil, 20550-900
Actively Recruiting
J
Juliana Borges, PhD
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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Gabriela Andrade Paz, Marcus Vds Rangel, Caio Luan Farias...
https://pubmed.ncbi.nlm.nih.gov/39944998