Actively Recruiting
Cardiac Rehabilitation and Coronary Artery Disease
Led by Instituto Nacional de Cardiologia de Laranjeiras · Updated on 2026-03-27
50
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
Sponsors
I
Instituto Nacional de Cardiologia de Laranjeiras
Lead Sponsor
R
Rio de Janeiro State University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients with coronary artery disease (CAD) aged 40-70 years will undergo exercise training (thrice weekly for 12 weeks). A reference group composed of healthy individuals will be included. Evaluations will be conducted at baseline and after the intervention period during two visits. During the first visit, carotid artery thickness will be assessed via ultrasound before and after a cardiopulmonary exercise testing. The second visit will include the evaluation of endothelial function using venous occlusion plethysmography. After this, participants will engage in 30 minutes of moderate-intensity aerobic exercise, and blood samples will be collected pre- and post-exercise. Circulating levels of kynurenine pathway (KP) metabolites (Tryptophan, kynurenine, kynurenic acid, and quinolinic acid), pro-inflammatory cytokines, cell adhesion molecules, and lipid profiles will be measured via Enzyme-Linked Immunosorbent Assay (ELISA), multiplex essays, and biochemical analysis; respectively.
CONDITIONS
Official Title
Cardiac Rehabilitation and Coronary Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 40 to 70 years
- Diagnosis of coronary artery disease including acute coronary syndrome, myocardial infarction, unstable angina, or obstructive CAD with ≥ 50% artery stenosis
- Both sexes eligible
- Healthy controls aged 40 to 70 years without evidence of coronary artery disease
- Matching by age and habitual physical activity level
You will not qualify if you...
- Diagnosis of heart failure, pulmonary disease, Chagas disease, or tuberculosis
- Regular physical exercise (≥ 3 days/week for 30 minutes) in the past 6 months
- Malnutrition with body mass index below 18.5 kg/m²
- Current smoking
- Obesity with body mass index of 30 kg/m² or higher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rio de Janeiro State University
Rio de Janeiro, Rio de Janeiro, Brazil, 20550-900
Actively Recruiting
Research Team
J
Juliana Borges, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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