Actively Recruiting
Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2024-07-24
150
Participants Needed
1
Research Sites
181 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic kidney disease (CKD) is prevalent worldwide and affects around 10% of people living in developed health economies. As the kidney loses its function in patients with CKD, the kidneys are unable to filter toxins out of the blood as efficiently as those of healthy individuals. Arguably, sodium (salt) is the most relevant toxin in CKD and can build up in the kidneys of patients with CKD. Salt build-up has also been found to occur in the heart muscle tissue and could drive the development of scarring of the heart muscle tissue which contributes to heart failure. Using sodium magnetic resonance imaging (MRI), we would like to measure the levels of salt in the heart muscle tissue. We will examine whether the heart muscle tissue has high salt levels, and if so, whether this relates to any heart defects. A conventional proton MRI will be done to measure heart function. The MRI images of healthy volunteers, CKD patients, and those on hemodialysis will be analyzed for levels of salt and the findings will then be compared to the cardiac biomarkers (proteins or enzymes that are released into the blood when the heart is damaged or stressed) and fibrosis (scarring) measured from each patient's proton MRI images to establish a possible correlation. This research has the potential to precede additional studies that may investigate the effect of diuretics (a drug that increases the production of urine) on the heart muscle tissue of CKD patients. Using sodium magnetic resonance imaging (MRI), it is possible to measure the sodium content in the cardiac tissue of patients with kidney disease. In this research study, it will be investigated whether the elevated levels of sodium in patients with kidney disease is also present in their hearts, and if so, whether this relates to cardiac abnormalities. Cardiac sodium MRI images of healthy volunteers, hemodialysis patients, and CKD patients will be analyzed for sodium content. This sodium information will then be compared to the biomarkers of cardiac function and fibrosis measured from each patient's proton MRI images in order to establish a possible correlation. This research has the potential to precede additional studies that may investigate the effect of diuretics on the cardiac tissue of kidney disease patients.
CONDITIONS
Official Title
Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than or equal to 18 years
- For patients on maintenance hemodialysis: more than 3 months duration of therapy
- For patients with chronic kidney disease: evidence of kidney disease persisting more than 3 months and no indications to start dialysis
- For healthy controls: no kidney disease, cardiovascular disease, diabetes, liver cirrhosis, or peripheral edema
You will not qualify if you...
- Pregnant, breastfeeding, or planning pregnancy
- Contraindications to MRI scan
- Inability to tolerate MRI due to patient size or known claustrophobia
- Presence of implanted mechanical, electrical, or magnetic devices or metal in the body that cannot be removed, including pacemakers, neurostimulators, insulin pumps, aneurysm clips, bioprosthesis, artificial limbs, metallic fragments, tattoos, shunts, surgical staples, or ear implants
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Victoria Hospital
London, Ontario, Canada, N6A5W9
Actively Recruiting
Research Team
C
Christopher W McIntyre, MD/PhD
CONTACT
T
Taylor L Marcus, BMSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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