Actively Recruiting
Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET/CT and MRI
Led by Bispebjerg Hospital · Updated on 2024-08-15
10
Participants Needed
1
Research Sites
29 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized crossover study aims to validate measurements of renal perfusion in healthy males with PET/CT, using 15-oxygen labeled water as tracer, against the validated multiparametric MRI technique. The study will determine: * Total renal blood flow and regional renal perfusion at baseline (rest) and during isometric muscle exercise of the upper arm, using PET/CT (with 15-oxygen labeled water as a tracer) and MRI. * The coefficient of variation of renal blood flow and regional renal perfusion measurements at baseline and during isometric muscle exercise of the upper arm, using PET/CT (with 15-oxygen labeled water as a tracer) and MRI. * Regional renal oxygenation and oxygen extraction at baseline and during isometric muscle exercise of the upper arm using MRI. * The coefficient of variation on regional renal oxygenation and oxygen extraction measurements at baseline and during isometric muscle exercise of the upper arm using MRI.
CONDITIONS
Official Title
Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET/CT and MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy males aged 20 to 60 years confirmed by medical questionnaire, examination, and blood tests.
You will not qualify if you...
- Use of immunosuppressive treatment.
- Alcohol abuse.
- Treatment with glucocorticoids, GLP-1 agonists, or DPP-4 inhibitors.
- Medical treatment affecting insulin secretion or cardiovascular endpoints.
- Liver disease.
- Decreased kidney function.
- Severe claustrophobia.
- Conditions incompatible with MRI scanning.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Bispebjerg Hospital, Department of Clinical Physiology & Nuclear Medicine
Copenhagen, Capital Region, Denmark, 2400
Actively Recruiting
Research Team
P
Peter Sørensen, MD
CONTACT
A
Ali Asmar, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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