Observational Study on Cardiometabolic Risk Factors and Outcomes in Adults with Heart Failure Including Different Heart Failure Types and Long-Term Follow-Up

What this Trial Is About

This research aims to understand how systemic and local cardiometabolic risk factors affect heart structure, function, and clinical outcomes in patients with heart failure HF. It includes patients with various HF types reduced, mildly reduced, preserved, and improved ejection fraction. The study combines retrospective clinical data from the past 10 years with a 5-year prospective follow-up to capture disease progression and risk patterns. The study evaluates metabolic factors like blood lipids, glucose levels, and insulin resistance, as well as localized fat deposits around the heart epicardial and perivascular adipose tissue measured by advanced imaging techniques such as cardiac MRI or CT. These factors are analyzed in relation to heart geometry changes, functional measures, transitions between HF types, and major cardiovascular events including re-hospitalization and cardiovascular death. Participants undergo initial standardized assessments including blood tests, echocardiography, and imaging, followed by clinical and biochemical evaluations every three months during the prospective phase. Retrospective data include historical imaging and lab results. Researchers will measure changes in heart function and structure at 12 months and track major cardiovascular events over 5 years. The study aims to improve risk assessment and guide personalized treatment for heart failure patients.

Cardiometabolic evalUation REgistry of Heart Failure