Actively Recruiting
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Led by University of Edinburgh · Updated on 2025-08-19
290
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Heart scarring, also known as fibrosis, is a key factor in various heart muscle diseases that can lead to serious problems like heart failure symptoms, dangerous heart rhythms, and even death. This research aims to use a new radioactive dye called 68Ga-FAPI to detect and understand patterns of heart muscle scarring. This dye has been used mainly to identify and monitor cancers but shows promise in revealing heart scarring, which may help us better understand disease processes and develop future targeted treatments. Participants will receive a baseline echocardiogram and a hybrid cardiac PET-MR scan using either 68Ga-FAPI or 18F-AlF-FAPI radiotracers at a dose of 200MBq. A follow-up echocardiogram and cardiac MRI will be performed approximately one year later to observe any changes in the heart muscle scarring. This imaging approach is being used to study several heart conditions including heart failure with preserved ejection fraction, hypertrophic cardiomyopathy, cardiac sarcoidosis, arrhythmogenic cardiomyopathy, myocarditis, and takotsubo cardiomyopathy. During the study, participants will undergo detailed heart scans and imaging tests at the start and after one year. Researchers will measure standardized uptake values and target-to-background ratios over 1 to 2 years to assess the heart scarring activity. The study includes monitoring heart function and structure using echocardiograms and MRI scans. The total participation time spans about one to two years, allowing researchers to track changes in the heart muscle over time.
CONDITIONS
Brief Title
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 30 to 90 years
- Provide informed consent before any study procedures
- Diagnosed with one of the following: heart failure with preserved ejection fraction with specific symptoms and echocardiographic features
- Diagnosed with hypertrophic cardiomyopathy meeting imaging and clinical criteria
- Diagnosed with essential hypertension for at least 1 year with evidence of left ventricular hypertrophy
- Diagnosed with arrhythmogenic right ventricular cardiomyopathy based on official criteria
- Diagnosed with myocarditis within the past month based on clinical and imaging features
- Diagnosed with takotsubo cardiomyopathy in the past month as defined by guidelines
- Diagnosed with cardiac sarcoidosis for at least 1 year with supporting biopsy or imaging findings and exclusion of other causes
You will not qualify if you...
- Unable or unwilling to give informed consent
- Claustrophobia or inability to tolerate lying down for PET/MR or PET/CT scans
- Kidney impairment with eGFR under 30 mL/min/1.73 m2
- Pregnant or breastfeeding women
- Allergy to iodine or gadolinium contrast
- Contraindications to CT scanning
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At baseline
Participants undergo baseline echocardiography and hybrid cardiac PET-MR with 200MBq of 68Ga-FAPI or 18F-AlF-FAPI to evaluate myocardial fibrosis.
1 visit (in-person)
Duration - 1 year
Participants receive a follow-up echocardiogram and cardiac MRI approximately one year later to assess changes in myocardial fibrosis.
2 visits (in-person) over 1 year
Trial Site Locations
Total: 1 location
1
University of Edinburgh
Edinburgh, Scotland, United Kingdom, EH16 5RR
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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