Actively Recruiting
Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors
Led by St. Jude Children's Research Hospital · Updated on 2026-04-23
100
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
SURVIVORS Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understand the link between long term effects of chest radiation and bleomycin for HL and brain function in survivors. Primary Objective To evaluate dynamic changes in CBF and oxygenation during exercise with Near Infrared Spectroscopy (NIRS) in HL survivors and non-cancer controls matched for age, sex, race, and ethnicity. . Secondary Objectives To examine the degree of CO2 clearance (DLCO/ETCO2) during rest and exercise in Hodgkin Lymphoma (HL) survivors compared to non-cancer controls matched for age, sex, race, and ethnicity. CONTROLS Volunteers are being asked to take part in this research study because they are non-first degree relative or friend of someone who received treatment for a childhood cancer or similar illness at St. Jude Children's Research Hospital or are an employee/affiliate of St. Jude Children's Research Hospital and have agreed to be a St. Jude Life Cohort Study (SJLIFE) community control.
CONDITIONS
Official Title
Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Completed bleomycin and/or thoracic radiation therapy for Hodgkin Lymphoma at St. Jude Children's Research Hospital
- Diagnosed with Hodgkin Lymphoma before age 21; currently 18 years or older and at least 2 years post therapy
- Participant in SJLIFE or ACT/SJLIFE studies
- Proficient in English
- For community controls: SJLIFE control participants
- 18 years or older at enrollment with age sampling to broadly match HL survivors
You will not qualify if you...
- History of cranial or total-body irradiation therapy
- History of intrathecal or high dose intravenous antimetabolite therapy
- History of head injury or diagnosis of a genetic disorder associated with cognitive impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
N
Nicholas Phillips, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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