Actively Recruiting
Cardiopulmonary Stress Testing (CPET) AlloSure Study
Led by Baylor Research Institute · Updated on 2026-01-22
27
Participants Needed
1
Research Sites
392 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. Cell-free DNA does not vary significantly as a function of the activity of immunologically quiescent cardiac transplant recipients, despite the metabolic demands of the transplanted organ. (The implication of the null result would be that no restrictions to patient activity, nor modification of cardiac rehabilitation prescription, would be necessary to maintain proper test characteristics of AlloSure testing). 2. In immunologically active cardiac transplant allografts, exercise prior to assay of donor-derived cell-free DNA can be used to increase the sensitivity of the AlloSure test. (The implication of this would be that the optimal time-frame for drawing an Allosure may actually be post-exercise, and that window will be characterized).
CONDITIONS
Official Title
Cardiopulmonary Stress Testing (CPET) AlloSure Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Post-orthotopic heart transplant patients
You will not qualify if you...
- Orthopedic, neurologic, or other limitations preventing exercise testing on a treadmill or cycle ergometer
- Requirement for supplemental oxygen or having a permanent tracheostomy
- Discharge to a long-term acute care facility
- Residence in a skilled nursing facility or receiving palliative or hospice care
- Being an inmate or pregnant woman
- Patients with antibody-mediated rejection deemed unsafe for cardiopulmonary stress testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Baylor Scott & White health research institute
Dallas, Texas, United States, 75246
Actively Recruiting
Research Team
A
Aayla Jamil, MBBS MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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