Effects of a 12-Week Moderate to High-Intensity Exercise Program on Cardiorespiratory Fitness in Children and Adolescents After Cancer Treatment

What this Trial Is About

Researchers are evaluating the effects of a 12-week moderate to high-intensity exercise program on cardiorespiratory fitness in children and adolescents who have completed acute cancer treatment. This trial focuses on pediatric patients aged 7 to 23 years and begins 6 weeks after finishing their cancer treatment. The study is a randomized controlled trial with 56 participants divided into two groups to compare exercise intervention with standard exercise recommendations. Participants in the intervention group will engage in two supervised exercise sessions each week one personal training session and one group-based session focusing on endurance, strength, mobility, and coordination. Both groups receive an initial consultation with general physical activity recommendations, a brochure, and a fitness tracker. The intervention group also receives daily activity targets adjusted biweekly. The study includes a control group receiving only exercise recommendations without supervised sessions. During the study, participants will undergo assessments at baseline, after 12 weeks of intervention, and at a 12-week follow-up to measure changes in maximal oxygen uptake VO2peak, muscle strength, mobility, balance, body composition, physical activity levels, quality of life, fatigue, cognitive function, and blood markers related to metabolic, immune, and heart health. Safety and adverse events will be monitored throughout. The total participation includes the 12-week intervention and a follow-up period extending to 24 weeks from study start.

Cardiorespiratory Fitness in Children and Adolescents After Cancer Treatment.