Actively Recruiting
CATCH-HF: Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure
Led by Hari Narayan · Updated on 2025-01-28
150
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of anthracycline chemotherapies, commonly used to treat pediatric cancer, which carry a risk of heart damage leading to heart failure and early cardiovascular death. The study aims to improve methods for identifying patients at risk before significant heart function changes occur by focusing on imaging markers of cardiac injury and dysfunction. This observational study includes adolescents and young adults with a history of childhood cancer to better understand the cardiotoxic effects of these treatments. Participants will undergo cardiac magnetic resonance imaging (MRI) to examine heart remodeling, function, and tissue characteristics. Physical activity will also be monitored using a hip-worn accelerometer. Testing will be done at the start of the study and again after at least three years to observe changes over time. During the study, participants will have cardiac MRI scans and physical activity assessments. Researchers will measure left ventricular ejection fraction (LVEF) over a 3 to 5-year period to evaluate heart function. The study will monitor participants long-term to better predict heart failure risk after cancer treatment, with total participation spanning several years including baseline and follow-up assessments.
CONDITIONS
Brief Title
Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- English and Spanish speaking male and female subjects, ages 13-39 years old
- Diagnosis of cancer at age less than 22 years
- Previously treated with anthracycline therapy for cancer, with diagnosis at least two years prior
You will not qualify if you...
- Contraindication to cardiac MRI, including non-MRI compatible metallic implants
- Medical, psychiatric, or social disorder preventing completion of study testing or cardiac MRI without anesthesia
- History of significant congenital heart disease (beyond patent foramen ovale or patent ductus arteriosus)
- Pregnancy at the time of enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo cardiac magnetic resonance imaging and physical activity monitoring to assess heart function and activity levels.
1 visit (in-person)
Duration - 3 years or more
Participants are assessed again at least 3 years after the initial evaluation to monitor heart health and function over time.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
Rady Children's Hospital
San Diego, California, United States, 92123
Actively Recruiting
Research Team
H
Hari Narayan, MD
C
Cesar Vasquez
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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