Actively Recruiting
Cardiovascular Disease Progression in Survivors of Community Acquired Pneumonia and Lung Infection by Covid-19.
Led by Hellenic Institute for the Study of Sepsis · Updated on 2026-02-17
650
Participants Needed
17
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pneumonia, which can be acquired in the community (including influenza and COVID-19), is a leading cause of mortality. The risk of severe cardiovascular diseases events (stroke, myocardial infarction, pulmonary embolism) increases after infections, but causal mechanisms are not understood yet. There is an essential need for improved understanding of the relationship between pneumonia and cardiovascular diseases and early identification of patients at risk of cardiovascular events to develop tailored therapies. The overall concept underpinning "Homi-lung" is to investigate the time course of host-microbiome interactions during \& after pneumonia to i) understand the causal relationship between trained immunity, microbiome dysbiosis and cardiovascular and respiratory diseases (CVRD) progressions, ii) define endotypes of pneumonia associated with response to treatment \& CVRD history; iii) develop biomarkers to predict the individual response to the treatment \& CVRD progression, and iv) preclinically validate therapeutical approaches for CVRD during \& after pneumonia.
CONDITIONS
Official Title
Cardiovascular Disease Progression in Survivors of Community Acquired Pneumonia and Lung Infection by Covid-19.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older of both genders
- No history of severe pneumonia (severe community-acquired pneumonia, COVID-19, or hospital-acquired pneumonia) for healthy controls
- Presence of no more than one of the following comorbidities for healthy controls: obesity (BMI over 35), type 2 diabetes mellitus, high cholesterol, essential hypertension, or family history of cardiovascular disease
- At least two of the following comorbidities for cardiovascular disease controls: obesity (BMI over 35), type 2 diabetes mellitus, high cholesterol, essential hypertension, or family history of cardiovascular disease
- Survivors of severe COVID-19 pneumonia treated with standard care including dexamethasone
- Survivors of severe community-acquired pneumonia treated with standard care including antibiotics
- Female/Male ratio approximately 50/50 in all groups
You will not qualify if you...
- Presence of two or more comorbidities for healthy controls
- Any co-existing disorder causing cardiovascular disease symptoms
- Limited survival chance of at least six months due to other comorbidities
- Pregnancy or lactation
- History of severe congestive heart failure (Stage III-IV)
- History of severe shortness of breath (Stage III-IV dyspnoea) before pneumonia episodes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
2nd Department of Internal Medicine, University General Hospital of Alexandroupolis
Alexandroupoli, Greece
Not Yet Recruiting
2
10th Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases
Athens, Greece
Actively Recruiting
3
1st Department of Internal Medicine, General Hospital of Athens G. GENNIMATAS
Athens, Greece
Actively Recruiting
4
1st Department of Internal Medicine, General Hospital of Athens KORGIALENIO-BENAKIO E.E.S.
Athens, Greece
Actively Recruiting
5
1st Department of Internal Medicine, General Hospital of Voula ASKLEPIEIO
Athens, Greece
Actively Recruiting
6
1st Intensive Care Clinic of the Medical School of the University of Athens, Evangelismos General Hospital
Athens, Greece
Actively Recruiting
7
1st University Department of Internal Medicine, General Hospital of Athens LAIKO
Athens, Greece
Actively Recruiting
8
1st University Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases
Athens, Greece
Actively Recruiting
9
2nd Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases
Athens, Greece
Actively Recruiting
10
3rd University Department of Internal Medicine, Sotiria Athens Hospital of Chest Diseases
Athens, Greece
Actively Recruiting
11
4th Department of Internal Medicine, ATTIKON University General Hospital
Athens, Greece
Actively Recruiting
12
Intensive Care Unit, General Hospital of Voula ASKLEPIEIO
Athens, Greece
Actively Recruiting
13
Out-patients clinic, General Hospital of Voula ASKLEPIEIO
Athens, Greece
Actively Recruiting
14
1st Department of Internal Medicine, Thriasio General Hospital of Elefsina
Elefsina, Greece
Not Yet Recruiting
15
1st Department of Internal Medicine, AHEPA University General Hospital of Thessaloniki
Thessaloniki, Greece
Not Yet Recruiting
16
Intensive Care Unit 2, AHEPA University General Hospital of Thessaloniki
Thessaloniki, Greece
Not Yet Recruiting
17
Intensive Care Unit, "Ippokrateion" General Hospital of Thessaloniki
Thessaloniki, Greece
Not Yet Recruiting
Research Team
P
Prof. Evangelos Giamarellos-Bourboulis
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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