Actively Recruiting
The Cardiovascular Impact of Hot Flushes
Led by University of Minnesota · Updated on 2026-05-07
60
Participants Needed
1
Research Sites
273 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall objective of this study is to examine the physiological responses that occur during a hot flush in postmenopausal women. The following specific aims will be executed to reach the overall objective of this study. Aim 1: To determine if hot flushes can be reliably induced with a temperature-controlled, water- circulating (TCWC) heating pad. Based on previous research, the investigators hypothesize that hot flushes will be inducible with the TCWC in symptomatic women, but not in asymptomatic women. Aim 2: To determine if heat-induced hot flushes in symptomatic women will cause reproducible cardiovascular and respiratory responses. The investigators hypothesize that heat-induced hot flushes produce similar and reproducible cardiovascular and respiratory responses to spontaneous hot flushes. Aim 3: To determine if body fat percentage influences hot flush severity or frequency during spontaneous or induced hot flushes. The investigators hypothesize that women with higher body fat have reduced hot flash severity and frequency.
CONDITIONS
Official Title
The Cardiovascular Impact of Hot Flushes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postmenopausal (may have or may not have hot flushes)
- Have not started hormone therapy and/or will discontinue hormone therapy for the duration of the study
You will not qualify if you...
- Reported nicotine/tobacco use within the last six months
- Diabetic or asthmatic
- Diagnosed significant carotid stenosis
- History of significant autonomic dysfunction, heart disease, respiratory disease, or severe neurologic condition such as stroke or traumatic brain injury
- Existing metabolic or endocrine abnormalities
- Use of heart/blood pressure medications that interfere with study outcomes
- Unwilling to discontinue use of hormonal contraceptives or menopausal hormone therapy
- Pregnant or breastfeeding
- Unwilling or unable to refrain from consuming caffeine or alcohol in the 12 hours before visits two or three
- Unwilling or unable to refrain from vigorous exercise for at least 10 minutes in the 12 hours before visits two or three
- Unwilling or unable to fast for eight hours before visits two or three
- Body mass index greater than or equal to 35 kg/m^3
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
M
Manda Keller-Ross, PhD, DPT, PT
CONTACT
W
William Stokes
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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