Actively Recruiting
Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation
Led by M.D. Anderson Cancer Center · Updated on 2026-03-11
100
Participants Needed
1
Research Sites
291 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study assesses cardiovascular injury and cardiac fitness in patients with non-small cell lung cancer that has spread to nearby tissue or lymph nodes (locally advanced) receiving model based personalized chemoradiation. The goal of this study is to learn more about the risk of developing heart disease as a result of chemoradiation treatment for lung cancer. Researchers also want to learn if the risk can be reduced by using a patient's individual risk profile to guide cancer treatment and help protect the heart.
CONDITIONS
Official Title
Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of non-small cell lung cancer, small cell lung cancer, or limited stage small cell lung cancer
- Recommended for thoracic radiation therapy combined with concurrent systemic therapy (chemotherapy and/or immunotherapy), with or without additional systemic therapy
- 18 years of age or older
- Karnofsky Performance Status (KPS) of 70 or higher
- Willing and able to sign informed consent
- Willing to perform the 6-minute walking test
- Willing to undergo required cardiac biomarker testing for primary endpoint assessment
You will not qualify if you...
- Unable or unwilling to provide written informed consent
- Previous thoracic radiation therapy overlapping with the current treatment area
- Pregnant or breastfeeding
- Renal failure requiring dialysis
- Unwilling to perform protocol tests
- Contraindications to any protocol tests
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
Z
Zhongxing Liao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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