Study of Heart Health and Fitness in Adults with Locally Advanced Non-Small Cell Lung Cancer Receiving Personalized Chemoradiation

What this Trial Is About

Researchers are evaluating cardiovascular injury and heart fitness in patients with locally advanced non-small cell lung cancer who are receiving model-based personalized chemoradiation. The study aims to understand the risk of heart disease caused by chemoradiation treatment and whether using a patients individual risk profile can help reduce this risk. This is an interventional study focusing on heart health during cancer treatment. Participants receive chemoradiation and undergo several assessments including single photon emission computed tomography SPECTcomputed tomography CT with stress tests, echocardiograms with strain, and 6-minute walk tests. These tests are done before radiation therapy, during treatment, and at multiple points up to 12 months after treatment. Blood samples are collected, and questionnaires are completed before treatment and over two years after treatment ends. The study includes two groups one receiving standard care and the other receiving personalized treatment based on models. Throughout the study, participants complete heart fitness tests and biomarker assessments at regular intervals during and after treatment. Follow-up visits occur up to 10 years to monitor survival and long-term heart health. Researchers measure heart injury using biomarkers like hs-TnT levels and track cardiovascular events, overall cardiac fitness, and patient-reported outcomes. This extensive monitoring helps researchers understand the impact of chemoradiation on heart health over time.

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation