Actively Recruiting
Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study
Led by Brigham and Women's Hospital · Updated on 2025-02-07
40
Participants Needed
1
Research Sites
219 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research study aims to learn more about the impact the hormone aldosterone on the heart. Primary aldosteronism is a condition where the body's adrenal glands make too much of the hormone aldosterone, which can cause high blood pressure and increase the risk of heart and kidney disease. Treatment with medications that block aldosterone can reduce that risk. This study is trying to learn whether treatment with a medication that blocks aldosterone can improve heart function in people who make too much aldosterone.
CONDITIONS
Official Title
Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 85 years
- Able to provide informed consent and willing to comply with the study
- Able to safely fit in the PET/CT scanner (weight limit 500 pounds; diameter 70 cm; circumference 220 cm)
- Hypertension treated with at least one antihypertensive drug
- Cohort A: Clinically confirmed diagnosis of primary aldosteronism not yet treated with mineralocorticoid receptor antagonists
- Cohort B: Clinically indicated cardiac PET perfusion scan within the preceding 3 months and echocardiogram within the preceding 6 months
You will not qualify if you...
- History of myocardial infarction, coronary artery bypass graft, known cardiomyopathy (EF less than 40%, hypertrophic cardiomyopathy, or amyloid), or cardiac transplantation
- Allergy or contraindication to eplerenone or spironolactone
- Current pregnancy or breastfeeding
- Estimated glomerular filtration rate less than 45 mL/min/1.73m2 or potassium level greater than 5.1 within the last 3 months
- Cohort A: Planned adrenalectomy within the next 6 months
- Cohort B: 10% or greater burden of ischemia on qualifying PET
- Cohort B: Planned coronary angiogram or revascularization within the next 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
J
Jenifer M Brown, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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