Actively Recruiting
Cardiovascular and Renal Endpoints With Flozins - an Observational Prospective Study in CKD HFpEF Patients
Led by Grigore T. Popa University of Medicine and Pharmacy · Updated on 2025-11-19
200
Participants Needed
1
Research Sites
155 weeks
Total Duration
On this page
Sponsors
G
Grigore T. Popa University of Medicine and Pharmacy
Lead Sponsor
D
Dr. C.I. Parhon Hospital, Iasi
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main aim of this study is to holistically assess the cardiovascular and renal outcomes in HFpEF CKD patients with and without SGLT2 inhibition, with focus on the endothelial disfunction, MACE and mortality using clinical evaluation, flow mediated dilatation, carotid-femoral pulse wave velocity, intima-media thickness, echocardiographic parameters, NMR metabolomics and a series of novel biomarkers.
CONDITIONS
Official Title
Cardiovascular and Renal Endpoints With Flozins - an Observational Prospective Study in CKD HFpEF Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 18 years
- Ejection fraction greater than 40%
- Patients with chronic kidney disease stage 3 or 4 (eGFR between 15 and 60 mL/min/1.73m2), diabetic or non-diabetic, with recommendation for SGLT2 inhibitors
- Age, sex, and CKD stage 3 or 4 matched patients without SGLT2 inhibitor treatment
You will not qualify if you...
- eGFR less than 15 mL/min/1.73m2 or patients undergoing dialysis
- Presence of congenital heart disease, decompensated cirrhosis, pregnancy, or active malignancies
- History of coronary artery disease including acute coronary syndrome, angina, or significant coronary artery lesions confirmed by angiography
- Presence of cardiac medical devices such as metallic joint prostheses, cardiac stents, or pacemakers
- Active systemic infections that may interfere with biomarker results
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Dr. C.I. Parhon Hospital in Iasi
Iași, Romania
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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