Actively Recruiting
Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period
Led by Pennington Biomedical Research Center · Updated on 2026-02-10
100
Participants Needed
1
Research Sites
238 weeks
Total Duration
On this page
Sponsors
P
Pennington Biomedical Research Center
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely understood. Habitual short sleepers are constantly eating, the proposed studies will evaluate if this behavior contributes to heightened cardiovascular and metabolic risk. The study will evaluate if restricted eating duration (8 hours/day) could improve cardiovascular and metabolic health in habitual short sleepers.
CONDITIONS
Official Title
Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 45 years
- Body mass index (BMI) between 25 and 35 kg/m2
- Habitual sleep duration of 6.5 hours or less per night
- Habitual eating period longer than 14 hours per day
- No chronic health conditions such as hypertension, dyslipidemia, diabetes, or cardiovascular disease, except prehypertension or prediabetes
- Individuals with seasonal allergies allowed
- Women of childbearing age must agree to use acceptable birth control during the study
- Ability to provide written informed consent
- Ability to follow the prescribed eating duration and maintain usual diet, sleep, and physical activity
- Use of certain medications allowed, including birth control, second-generation antihistamines, antacids, and acne ointments
You will not qualify if you...
- Irregular sleep habits or night/rotating shift work in the past month
- Frequent travel causing jet lag
- Pregnant, breastfeeding, or history of irregular menstrual cycles
- Sleep disorders such as insomnia (Insomnia Severity Index score 15 or higher) or sleep apnea (oxygen desaturation index over 10 events per hour)
- Excessive daytime sleepiness (Epworth Sleepiness Scale score over 10)
- Recent body weight changes of 5% or more within 3 months
- Uncontrolled depression or anxiety, history of psychosis or bipolar disorder
- Depression defined as PHQ-9 score of 15 or higher or suicidal thoughts
- Any medication or condition that could interfere with study outcomes or risk participant safety
- Blood or plasma donation within the past 2 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Recruiting core Pennington
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
Research Team
P
Prachi Singh, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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