Actively Recruiting
CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain)
Led by Wake Forest University Health Sciences · Updated on 2026-04-06
502
Participants Needed
3
Research Sites
204 weeks
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
A
Agency for Healthcare Research and Quality (AHRQ)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to determine if rapid outpatient evaluation vs hospitalization management is the best strategy (based on patient-centered measures and safe, equitable, and efficient resource use) for evaluating patients with acute chest pain who are at moderate risk for acute coronary syndrome (ACS). Patients will be randomized in the Emergency Department to either an outpatient evaluation (CARE-CP) or hospitalization evaluation for their symptoms.
CONDITIONS
Official Title
CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 years of age or older
- Chest pain or symptoms of acute coronary syndrome (ACS)
- Moderate risk of ACS with a Heart Score between 4 and 6
- Non-ischemic electrocardiogram (ECG)
- Two troponin measurements below sex-specific upper reference limits (Women <15 pg/ml, Men <20 pg/ml)
- No prior coronary artery disease, including no previous myocardial infarction or coronary revascularization procedures
- No patients with 70% or greater obstructive coronary disease
You will not qualify if you...
- ST Elevation Myocardial Infarction (STEMI) activation
- ST changes or new T-wave inversions ≥1mm on ECG
- Any elevated troponin measurement based on sex-specific 99th percentile
- Serial change between troponin measures (delta) ≥5 pg/mL
- Stress echocardiography, nuclear stress test, stress ECG, stress cardiac MRI, coronary CT angiogram, or invasive coronary angiography within 1 year
- "Clean" coronary CT angiogram or cardiac catheterization (0% stenosis in all vessels) within the past 2 years
- Chest trauma
- Pregnancy
- Life expectancy less than 1 year
- Other comorbid conditions requiring hospitalization
- Unstable vital signs (blood pressure <90, heart rate >120 or <50, oxygen saturation <90%)
- End stage renal disease, dialysis, or estimated glomerular filtration rate (eGFR) <30 mL/min
- Transfers from another hospital
- Non-English speaking
- Prisoners
- Prior enrollment in this study
- Already enrolled in another interventional trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
2
Carolinas Medical Center
Charlotte, North Carolina, United States, 28203
Actively Recruiting
3
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
Research Team
L
Lauren Koehler
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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