CARE-CRC Study Investigating Gut Microbiome Markers and Lifestyle Links in Colorectal Cancer for Adults Aged 40 to 74

What this Trial Is About

This research aims to develop a non-invasive diagnostic tool based on the gut microbiome to improve early detection of colorectal cancer CRC, focusing particularly on early-onset CRC EoCRC in people under 50. CRC is a leading cause of cancer deaths worldwide, with rising cases among younger adults who often face delayed diagnosis. The study explores how lifestyle factors and gut microbiome changes may contribute to CRC risk and progression. Participants diagnosed with CRC but not yet treated will be included, aged 40 to 74 years. Faecal and blood samples will be collected at diagnosis, after treatment, and during a three-year follow-up. The study will analyze microbiome profiles, clinical data, and lifestyle factors such as diet, physical activity, stress, and body mass index. A control group of healthy individuals undergoing routine screening colonoscopies will also be recruited. During the study, researchers will monitor survival rates, disease progression, and therapeutic responses while assessing microbiome changes and lifestyle impacts. Data will be gathered through questionnaires and interviews about diet and habits. Microbiome analysis will use advanced sequencing methods to identify biomarkers linked to CRC stages, prognosis, and treatment outcomes over three years, aiming to support personalized prevention and care strategies.

CARE-CRC: Microbiome Insights and Correlations for Risk and Outcomes in Colorectal Cancer