Care of the Urothelial Cancer Patient and Prospective Collection of Biospecimens From Healthy Volunteers and Urothelial Cancer Patients

What this Trial Is About

Urothelial cancer affects the bladder, ureter, and urethra, and researchers aim to understand the cellular and genetic changes that cause this cancer to develop. This knowledge may help identify new treatment options. The study focuses on collecting and analyzing tissue and other biological samples to explore molecular differences between normal and tumor tissues, and to predict disease progression and treatment responses. Participants include adults with biopsy-proven or suspected urothelial cancer, as well as healthy volunteers. Patients will undergo diagnostic or therapeutic procedures as part of their standard care, during which tissue samples may be collected and stored in a tissue bank. Blood, urine, and saliva samples will also be collected from both patients and healthy volunteers. No experimental treatments are given; care follows medically indicated standards. During the study, participants will have physical exams, medical record reviews, and sample collections including blood, urine, saliva, and tissue. Patients may have imaging scans and follow-up visits every six months, with ongoing health status updates collected by phone. Researchers will analyze these samples and clinical data to study the molecular mechanisms of urothelial cancer and develop potential new therapies. Participation may last several years, with ongoing sample and data collection.

Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue