Study of Urothelial Cancer Patients and Healthy Volunteers to Collect Tissue and Samples for Research on Cancer Causes and Treatments

What this Trial Is About

Urothelial cancer, affecting the bladder, ureter, and urethra, is being studied to understand the cellular and genetic changes that cause this cancer. Researchers aim to learn how molecular and gene changes may predict disease progression and treatment response. This observational study involves adults aged 18 and older with urothelial cancer or those suspected of having it, as well as healthy volunteers, to compare molecular differences. Participants will provide tissue samples from their original tumors, which will be stored in a tissue bank for research. Blood, urine, and saliva samples will also be collected from both patients and healthy volunteers. If surgery is needed, additional tissue samples may be taken during the procedure. No experimental treatments are given in this study care follows standard medical practices. Throughout the study, participants will undergo medical exams, imaging, and sample collection at baseline and follow-up visits. They will return to the clinical center six months after initial participation for further sample collection and will then continue routine care with their local doctors. Researchers will monitor health updates by phone every six months to better understand urothelial cancers molecular mechanisms and clinical outcomes.

Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue