Actively Recruiting
Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue
Led by National Cancer Institute (NCI) · Updated on 2026-04-02
500
Participants Needed
1
Research Sites
633 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Urothelial cancer is cancer of the bladder, ureter, and urethra. Researchers want to better understand what changes in a person s cells and genes cause this cancer to form. This may help them find new ways to treat it. Objective: \- To perform DNA sequencing to help researchers learn the differences between normal tissue and tumor tissue. Also, to learn how molecular changes - including gene changes - might help predict the course of disease and how people respond to therapy. Eligibility: \- Adults age 18 and older who have or are suspected of having urothelial cancer or an inherited disorder that raises their risk of getting bladder cancer. Design: * Participants will be screened with a physical exam. Their medical records and tissue samples will be reviewed. * Eligible participants will give tissue blocks of their original tumor. The blocks will be put in a tissue bank. * Participants medical records may be reviewed. * Participants may have a medical history and physical exam. * Participants may have blood and urine tests. They may have imaging scans. They may give urine, blood, and saliva samples. These samples may be used in future research. * If participants need surgery for their cancer, researchers will keep some of the tissue (both tumor and normal tissue). The tissue may be used in future research. * Participants will go back to the Clinical Center in 6 months. They may give saliva, urine, and blood samples. After 6 months, they will be seen by their local doctor for standard post-surgical visits. * Participants will be called every 6 months to give health updates.
CONDITIONS
Official Title
Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years of age or older with biopsy-proven or suspected urothelial cancer who require or are willing to undergo diagnostic or therapeutic intervention as part of their diagnosis, standard of care treatment, or follow-up/surveillance
- ECOG performance status of 0 to 3
- Willing and able to provide informed consent
- Healthy volunteers 18 years or older able to give informed consent
You will not qualify if you...
- Pregnant subjects
- Subjects with co-morbidities that prevent diagnostic or therapeutic intervention, including ongoing treatment for another non-skin malignancy
- History of hepatitis B, hepatitis C, or HIV infection
- Healthy volunteers who are family members with germline mutations
- Healthy volunteers with heart, lung, kidney disease, or other medical conditions as determined by the Principal Investigator
- Diagnosis of cancer requiring treatment other than minor resection of basal cell or squamous cell skin cancers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
L
Lidenys C O'Brien Gutierrez
CONTACT
R
Raju R Chelluri, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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