Actively Recruiting
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
Led by Unity Health Toronto · Updated on 2026-01-16
740
Participants Needed
33
Research Sites
301 weeks
Total Duration
On this page
Sponsors
U
Unity Health Toronto
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a basket trial design examines a single intervention in multiple disease populations. CAVIARDS consists of an identical 2-arm mechanical ventilation protocol implemented in two different study populations (COVID-19 and non-COVID-19 patients). As per a typical basket trial design, the operational structure of both the COVID-19 substudy (CAVIARDS-19) and non-COVID-19 substudy (CAVIARDS-all) is shared (recruitment, procedures, data collection, analysis, management, etc.).
CONDITIONS
Official Title
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Moderate or severe ARDS with PaO2/FiO2 ratio of 200 mmHg or less within 48 hours of meeting Berlin ARDS criteria
- Patients whose PaO2/FiO2 ratio improved above 200 mmHg under prone positioning at protocol start remain eligible
You will not qualify if you...
- Received continuous mechanical ventilation for more than 7 days
- Known or suspected elevated intracranial pressure greater than 18 mmHg requiring strict CO2 control
- Known pregnancy
- Presence of broncho-pleural fistula
- Severe liver disease with Child-Pugh Score of 10 or higher
- Body mass index (BMI) over 40 kg/m2
- Anticipation of withdrawal of life support or shift to palliative care
- Receiving extracorporeal membrane oxygenation (ECMO) at time of randomization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 33 locations
1
New York University Grossman School of Medicine
New York, New York, United States, 10016
Actively Recruiting
2
Centro de Educación Médica e Investigaciones Clínicas Dr Norberto Quirno (CEMIC)
Buenos Aires, Argentina
Actively Recruiting
3
Complejo Médico Policía Federal Argentina Churruca Visca
Buenos Aires, Argentina
Actively Recruiting
4
Hospital Británico de Buenos Aires
Buenos Aires, Argentina
Actively Recruiting
5
Sanatorio Anchorena Recoleta
Buenos Aires, Argentina
Actively Recruiting
6
Sanatorio Mater Dei
Buenos Aires, Argentina
Actively Recruiting
7
Sanatorio Anchorena San Martín
San Martin, Argentina
Actively Recruiting
8
St. Michael's Hospital
Toronto, Canada
Actively Recruiting
9
Toronto General Hospital
Toronto, Canada
Actively Recruiting
10
Toronto Western Hospital
Toronto, Canada
Actively Recruiting
11
Pontificia Universidad Católica de Chile
Santiago, Chile
Actively Recruiting
12
CHU Amiens-Picardie
Amiens, France
Actively Recruiting
13
Centre hospitalier universitaire d'Angers
Angers, France
Actively Recruiting
14
CH Victor Dupouy
Argenteuil, France
Actively Recruiting
15
CH de Beauvais
Beauvais, France
Actively Recruiting
16
CHU Bordeaux - Haut Leveque
Bordeaux, France
Actively Recruiting
17
Hopital de la Cavale Blanche - CHRU Brest
Brest, France
Actively Recruiting
18
CH de Cholet
Cholet, France
Actively Recruiting
19
Hopital Intercommunal de Creteil
Créteil, France
Actively Recruiting
20
CHU Grenoble-Alpes
Grenoble, France
Actively Recruiting
21
Hopital Roger Salengro - CHU Lille
Lille, France
Actively Recruiting
22
Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Mulhouse, France
Actively Recruiting
23
Hopital de l'Archet 1 - CHU de Nice
Nice, France
Actively Recruiting
24
Hopital Europeen Georges-Pompidou
Paris, France
Actively Recruiting
25
CHU de Poitiers - La Miletrie
Poitiers, France
Actively Recruiting
26
CH Bretagne Atlantique Vannes-Auray
Vannes, France
Actively Recruiting
27
HIA Robert Picque
Villenave-d'Ornon, France
Actively Recruiting
28
Arcispedale Sant'Anna
Ferrara, Italy
Actively Recruiting
29
University of Foggia
Foggia, Italy
Actively Recruiting
30
Policlinico Universitario Agostino Gemelli IRCCS
Rome, Italy
Actively Recruiting
31
OLVG
Amsterdam, North Holland, Netherlands
Actively Recruiting
32
L'Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Actively Recruiting
33
Vall d'Hebron University Hospital
Barcelona, Spain
Actively Recruiting
Research Team
L
Laurent Brochard, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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