Actively Recruiting
Caregiver Stress and Bereavement
Led by University of Zurich · Updated on 2025-04-04
150
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
Sponsors
U
University of Zurich
Lead Sponsor
U
University of Salzburg
Collaborating Sponsor
AI-Summary
What this Trial Is About
The death of a spouse is considered one of the most stressful and impactful life events and is associated with increased morbidity and premature mortality. Early identification of individuals who are most at risk for poor health outcomes following bereavement is an important aim of precision medicine and disease prevention initiatives. A better understanding of caregiver burden and bereavement-related distress and its implication for health is a clinically-relevant step toward the development of treatments that improve health outcomes in bereaved spouses. This study aims to map profiles of individual differences in short- and long-term adjustment to loss, according to psychological (e.g., depression, stress, grief severity) and biological markers (e.g., inflammation, cortisol) over time.
CONDITIONS
Official Title
Caregiver Stress and Bereavement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant age 65 18 years
- Caregiver or spouse of a patient suffering from a terminal illness with an estimated life expectancy 64 6 months
- Regarded as the patient's primary caregiver involved in daily care, medication supervision, hospital visits, inpatient stays, and communication with hospital staff
- German as primary language
- Signed informed consent
You will not qualify if you...
- Significant visual or auditory problems or cognitive impairment
- Morbid obesity (body mass index 65 40 kg/m2)
- Alcohol or drug abuse
- Active malignancy
- Severe illness including respiratory, heart, liver, or renal failure
- Major medical conditions involving the immune system such as diabetes type 1 or 2, autoimmune or inflammatory diseases including rheumatoid arthritis, ulcerative colitis, asthma, thyroid diseases
- Severe hypertension (>200/120 mmHg)
- Regular use of medication with major immunological consequences such as corticosteroids or immunosuppressive therapy
- Pregnant or breast-feeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Zurich
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
A
Annina Seiler, PD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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