Study on Psychological and Biological Responses to Spousal Loss in Terminal Cancer Caregivers

What this Trial Is About

The loss of a spouse, especially after caring for a terminally ill partner, is a highly stressful event linked to increased risk of mental and physical health problems. This research investigates how individual differences in psychological factors like depression and grief, along with biological markers such as inflammation and cortisol levels, influence short- and long-term adjustment to bereavement. The study seeks to understand why some people develop prolonged grief or health issues while others show resilience. Participants are caregivers or spouses of patients with terminal illnesses expected to live six months or less. The study observes these individuals over time, assessing psychological and biological markers before and after the patients death. Measurements occur at three points six months before the patients death, 3-6 months post-loss, and 9-12 months post-loss. Data collected include depression scales, inflammatory markers, stress inventories, sleep quality, heart rate variability, and other health questionnaires. During the study, participants complete various questionnaires and provide biological samples at each assessment point. Researchers track psychological symptoms, stress levels, immune and endocrine function, and physical health to identify patterns of adjustment to loss. The study aims to reveal factors influencing resilience or vulnerability after bereavement, helping to guide future treatments to support health outcomes in grieving spouses. Participation spans from before the patients death through one year after the loss, with multiple evaluations along the way.

Caregiver Stress and Bereavement