Actively Recruiting
Carotid Artery Corrected Flow Time and Respiratory Variation of Blood Flow Peak Velocity for Prediction of Hypotension After Induction of General Anaesthesia in Adult Patients With Chronic Liver Disease
Led by Ain Shams University · Updated on 2026-02-02
35
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are investigating how measurements of the carotid artery, specifically the corrected flow time and respiratory variation of peak blood flow velocity, can predict hypotension after general anesthesia induction in adults with chronic liver disease. The study includes adult patients with confirmed chronic liver disease undergoing elective surgery and aims to monitor blood flow and hemodynamic changes during anesthesia to better understand hypotension risks. During the study, patients will undergo ultrasound measurements of the carotid artery while lying on their backs to capture blood flow details using a specialized ultrasound device. Anesthesia will be administered with a standardized protocol including medications like propofol, fentanyl, and cisatracurium. Continuous monitoring of heart rate, blood pressure (using arterial catheter), oxygen levels, and carbon dioxide will be performed before and after anesthesia induction. Patients will be grouped based on whether they experience post-induction hypotension. Participants will be closely observed throughout the surgery with vital signs continuously recorded for 5 to 10 minutes after anesthesia induction. Ultrasound measures will be taken by experienced sonographers, and some results will be reviewed for consistency. The main outcome is to predict hypotension within the first three months. Treatments for hypotension and bradycardia will be applied as needed. The total study duration is about three months or until enough participants are recruited.
CONDITIONS
Brief Title
Carotid Artery Corrected Flow Time and Respiratory Variation of Blood Flow Peak Velocity for Prediction of Hypotension After Induction of General Anaesthesia in Adult Patients With Chronic Liver Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older
- Confirmed diagnosis of chronic liver disease such as cirrhosis or non-alcoholic steatohepatitis
- Scheduled for elective surgery under general anesthesia
- American Society of Anesthesiologists (ASA) physical status 2, 3, or 4
- ASA 4 patients must have a baseline mean arterial pressure (MAP) greater than 65 mmHg
You will not qualify if you...
- Refusal to participate in the study
- Known severe cardiac disease such as severe valvular disease or congestive heart failure
- Pre-existing severe hypotension with mean arterial pressure (MAP) less than 65 mmHg
- Emergency surgery cases
- Anatomical variations that prevent clear ultrasound visualization of the carotid artery
- Carotid artery stenosis
- Mean arterial pressure (MAP) greater than 120 mmHg before anesthesia
- Previous neck surgery or trauma
- Acute renal injury
- Use of oral angiotensin receptor blockers or angiotensin-converting enzyme inhibitors (ACEI)
- Surgeries in lateral, prone, or lithotomy positions
- Body mass index (BMI) greater than 30 kg/m2 or less than 15 kg/m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Day of surgery
Participants undergo ultrasound assessments of the carotid artery to evaluate blood flow and predict hypotension after anesthesia induction.
1 visit (in-person)
Duration - 3 months
Participants are observed for the occurrence of hypotension and other outcomes for up to 3 months after surgery.
Trial Site Locations
Total: 1 location
1
Ainshams University
Cairo, Egypt
Actively Recruiting
Research Team
I
ismail mohammed mahmoud, assistant professor
T
tamer samir abdelsalam, assisstant professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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