Study of Immediate Carotid Artery Stenting During Endovascular Treatment in Adults With Acute Ischemic Stroke and Carotid Artery Narrowing

What this Trial Is About

Researchers are evaluating the safety and effectiveness of immediate carotid artery stenting CAS during endovascular thrombectomy EVT in patients who have an acute ischemic stroke caused by a large vessel blockage in the brain and a high-grade narrowing or blockage of the carotid artery. This study compares immediate CAS during EVT with deferred treatment or medical management alone. It aims to determine if placing a stent right away improves blood flow and reduces the risk of another stroke, while monitoring for possible complications like bleeding. The study randomly assigns patients to two groups. One group receives CAS during EVT, with the stent placed either just before or directly after removing the brain clot. The other group follows current guidelines they may have carotid surgery or stenting later if they have a less severe stroke, or receive medical management alone if the stroke is severe. This design helps compare immediate stenting versus deferred or no stenting approaches. Participants will be assessed through several measures including the modified Rankin Scale at 90 days to evaluate disability, NIH Stroke Scale scores at 24 hours, brain imaging to check blood flow and infarct size, and monitoring for stroke recurrence or artery re-occlusion. Quality of life and survival will also be followed for three months. The total study duration is from November 2022 to November 2026, with blinded evaluation of outcomes to ensure unbiased results.

Carotid Artery Stenting During Endovascular Treatment of Acute Stroke