Actively Recruiting
Carotid Atherosclerosis: Evaluating Imaging Biomarkers to Predict Stroke Risk in a Case-Control Study
Led by Hospices Civils de Lyon · Updated on 2026-04-03
77
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
H
Hospices Civils de Lyon
Lead Sponsor
F
Fondation de France
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cerebrovascular accident (CVA), or stroke, is a major public health issue and the second leading cause of cardiovascular death. About 80% of CVA cases are ischemic, with large artery atheroma, especially in the carotid artery, responsible for about 20% of cases. This research aims to evaluate advanced imaging methods that assess carotid plaque vulnerability and inflammation, which may predict stroke risk better than traditional narrowing measurements alone. The study is a case-control design including both patients who have had an ischemic stroke and those with carotid stenosis without stroke to compare plaque characteristics.
CONDITIONS
Brief Title
Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Carotid artery stenosis of at least 50% according to NASCET criteria
- For cases: ischemic stroke on the same side as carotid stenosis confirmed by MRI or CT within the past month with no other stroke causes
- For controls: no clinical or MRI evidence of recent stroke
- Signed informed consent form
- Patient affiliated with a social security system or equivalent
You will not qualify if you...
- Modified Rankin scale greater than 3
- Stroke or transient ischemic attack on the same side more than 1 month ago
- History of carotid surgery on the same side, cervical radiation, carotid occlusion, or intracranial stenosis on the same side
- Risk of arterial thromboembolic events
- Renal failure with creatinine clearance less than 50 ml/min
- Contraindications to ultrasound contrast agent (Sonovue)
- Contraindications to MRI or its contrast agent (Gadolinium)
- Unable to sign informed consent
- Unable to undergo study procedures (e.g., due to claustrophobia)
- Serious co-morbid diseases or dementia
- Neurological disease without carotid disease
- Pregnancy, breastfeeding, or risk of pregnancy
- Under reinforced guardianship or legal guardianship
- Inability to understand French language
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo imaging and ultrasound examinations to evaluate carotid artery plaque characteristics and stroke risk.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Hospices Civils de Lyon - Service de radiologie
Bron, France, 69500
Actively Recruiting
Research Team
P
Philippe DOUEK, MD
A
Adeline MANSUY, CRA
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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