Actively Recruiting
Castrate Resistant Prostate Cancer Enhertu Therapy
Led by Washington D.C. Veterans Affairs Medical Center · Updated on 2026-04-13
60
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
Sponsors
W
Washington D.C. Veterans Affairs Medical Center
Lead Sponsor
D
Daiichi Sankyo
Collaborating Sponsor
AI-Summary
What this Trial Is About
Use of Enhertu as a Subsequent Line of Therapy in HER2-Positive Metastatic Castration-Resistant Prostate Adenocarcinoma.
CONDITIONS
Official Title
Castrate Resistant Prostate Cancer Enhertu Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed adenocarcinoma of the prostate
- Diagnosis of metastatic castration-resistant prostate cancer (mCRPC)
- Documented progression on androgen deprivation and novel hormonal agents, with or without progression on taxane containing regimen
- Ongoing androgen deprivation therapy to maintain serum testosterone levels below 50 ng/dL
- Availability of formalin fixed paraffin embedded tumor tissue for HER2 immunohistochemistry
- Life expectancy of at least 6 months
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
- Left ventricular ejection fraction (LVEF) of at least 50%
- Adequate blood clotting function
- Adequate organ and bone marrow function
- Adequate renal function
- Adequate hepatic function
You will not qualify if you...
- History of interstitial lung disease or pneumonitis requiring steroids
- Significant coronary vascular disease
- Previous exposure to HER2 targeted therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington DC VAMC
Washington D.C., District of Columbia, United States, 20422
Actively Recruiting
Research Team
A
Asha Escobar
CONTACT
M
Martha Antonio
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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