Actively Recruiting
Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies
Led by Yale University · Updated on 2025-06-11
258
Participants Needed
22
Research Sites
220 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
C
Children's Hospital Colorado
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of the CRETE Studies is to investigate the newly identified age-dependent heterogeneity in the efficacy of enoxaparin in reducing the risk of central venous catheter-associated deep venous thrombosis in critically ill children.
CONDITIONS
Official Title
Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Older than 36 weeks corrected gestational age and younger than 17 years old
- Less than 24 hours after insertion of an untunneled central venous catheter (CVC)
- CVC inserted in the internal jugular or femoral vein
You will not qualify if you...
- Radiologic diagnosis of catheter-associated deep venous thrombosis (CADVT) at the insertion site within the prior 6 weeks
- Currently receiving an antithrombotic agent, such as low molecular weight heparin, unfractionated heparin, warfarin, or aspirin (except unfractionated heparin for catheter patency)
- Clinically relevant bleeding in the prior 60 days, including significant hemoglobin decrease or bleeding requiring medical or surgical intervention
- Surgery or major trauma in the prior 7 days
- Coagulopathy with elevated INR, aPTT, or low platelet count
- Renal failure with creatinine clearance less than 30 mL/min/1.73 m2
- Known allergy to heparin or pork products
- Laboratory-confirmed heparin-induced thrombocytopenia (HIT)
- Current pregnancy or breastfeeding
- Presence of an epidural catheter
- Limitations of care
- Previous enrollment in the CRETE Studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 22 locations
1
Children's of Alabama
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202
Actively Recruiting
3
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
4
Yale-New Haven Children's Hospital
New Haven, Connecticut, United States, 06520
Actively Recruiting
5
University of Florida -UF Health
Gainesville, Florida, United States, 32610
Actively Recruiting
6
Johns Hopkins All Children's
St. Petersburg, Florida, United States, 33701
Actively Recruiting
7
Children's Hospital of Illinois at OSF Saint Francis Medical Center
Peoria, Illinois, United States, 61637
Actively Recruiting
8
Stead Family Children's Hospital
Iowa City, Iowa, United States, 52242
Actively Recruiting
9
Children's Hospital St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
10
Hassenfeld Children's Hospital
New York, New York, United States, 10016
Actively Recruiting
11
New York Presbyterian Hospital
New York, New York, United States, 10065
Actively Recruiting
12
Golisano Children's Hospital
Rochester, New York, United States, 14642
Actively Recruiting
13
Maria Fareri Children's Hospital
Valhalla, New York, United States, 10595
Actively Recruiting
14
UH Rainbow Babies & Children's Hospital
Cleveland, Ohio, United States, 44106
Actively Recruiting
15
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Withdrawn
16
University of Oklahoma
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
17
Penn State Hershey Children's Hospital
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
18
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
19
Dell Children's Medical Canter
Austin, Texas, United States, 78723
Actively Recruiting
20
UTSW Medical Center; Children's Medical Center of Dallas
Dallas, Texas, United States, 75235
Actively Recruiting
21
Children's Hospital of Richmond
Richmond, Virginia, United States, 23219
Withdrawn
22
Children's Hospital Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
E
E. Vincent Faustino, MD, MHS
CONTACT
T
Tara McPartland, MSW, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
5
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