Actively Recruiting
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Led by Florida State University · Updated on 2026-03-11
72
Participants Needed
1
Research Sites
131 weeks
Total Duration
On this page
Sponsors
F
Florida State University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulation for participants that are within a unipolar major depressive episode and also have high symptoms of anhedonia.
CONDITIONS
Official Title
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between the ages of 18 and 65
- Able to provide informed consent
- Have normal to corrected vision
- Willing to comply with all study procedures and be available for the duration of the study
- Speak and understand English
- Mild suicide risk as determined by the Hamilton Depression Rating Scale (HAM-D; less than 3 for the suicidality item) and non-existent or mild risk according to the Depression Symptom Index Suicidality Subscale (DSI-SS)
- Patient Health Questionnaire (PHQ-8) greater than or equal to 8 prior to the first session
- Snaith Hamilton Pleasure Scale (SHAPS) greater than 33 at the first session
- A diagnosis of major depressive disorder on the Mini International Neuropsychiatric Interview for the DSM-V (MINI)
You will not qualify if you...
- Currently receiving treatment for ADHD
- History of neurological disorders or conditions including epilepsy (except childhood febrile seizures), seizures, dementia, stroke, Parkinson's disease, multiple sclerosis, cerebral aneurysm, or brain tumors
- Medical or neurological illness or treatment that could interfere with the study, such as unstable cardiac disease, HIV/AIDS, malignancy, liver or kidney problems
- Prior brain surgery
- Any brain devices or implants such as cochlear implants, aneurysm clips, cardiac pacemakers, or other implanted electronic devices
- History of current traumatic brain injury
- Pregnancy (for females)
- Current severe substance use disorder
- Claustrophobia
- Metal in the body that is ferrous, tattoos on face or neck, metal jewelry or clothing with metal, metal workers, or eye injury involving metal
- Anything the investigator judges would increase risk or prevent full participation
- DSM-V diagnosis of moderate or severe substance or alcohol use disorder currently or severe disorder in the past 12 months, or psychotic disorder within the last year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Florida State University
Tallahassee, Florida, United States, 32306
Actively Recruiting
Research Team
J
Justin M Riddle, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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