3D Imaging (Cone Beam Computed Tomography) Versus Orthopantomogram on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis: a Multicenter Randomized Superiority Controlled Trial.

What this Trial Is About

Infective Endocarditis (IE) is a serious and rare disease with high rates of complications and death. Streptococci from the mouth are the second most common cause of IE. The usual clinical exam combined with Orthopantomogram (OPT) imaging often misses oral infectious foci (OIF), which may contribute to IE. Cone Beam Computed Tomography (CBCT) is thought to detect these oral infections more accurately, but its impact on oral health in IE patients has not been studied before. This trial compares two approaches to oral examination in patients hospitalized for IE: the standard clinical exam with OPT and the newer clinical exam with CBCT. Participants will be randomly assigned to either the OPT group or the CBCT group. The study aims to see if CBCT improves oral health status over 12 months and if it can better detect oral infectious foci. Participants will be monitored over 12 months with evaluations at the start and after one year. These include assessments of oral hygiene, detection of symptomatic and asymptomatic oral infections, and oral health quality of life. Researchers will also track patients' dental follow-up habits and any premature study discontinuation. The main measure is whether CBCT offers superiority in oral health outcomes at 12 months compared to OPT. The study is sponsored by Nantes University Hospital and runs until mid-2028.

CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.