Actively Recruiting
CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.
Led by Nantes University Hospital · Updated on 2026-04-06
170
Participants Needed
10
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1\. Infective Endocarditis (IE) is a rare and serious disease with high morbidity and mortality; 2. Streptoccoci of oral origin are the second more frequent microorganisms responsible for IE; 3. Oral Infectious Foci (OIF) are underdetected using the current recommended clinical examination/Orthopantomogram (OPT) approach; 4. Cone Beam Computed Tomography (CBCT) has a better sensitivity and sensibility to detect OIF than OPT; 5. To date, no study has been performed to assess the potential benefit of a clinical examination/CBCT approach on the oral health status in IE patients. Thus, conducting a randomized controlled trial is highly desirable to assess the potential impact of a clinical examination/CBCT approach on the oral health status of patients hospitalized for IE and potentially to reduce IE new episodes.
CONDITIONS
Official Title
CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized or recently hospitalized for definite Infective Endocarditis (IE) as per 2015 ESC classification
- Naive to dental examination and imaging regardless of IE microorganism
- Clinically stable and out of critical phase, able to undergo OPT and CBCT imaging
- Expected life expectancy longer than 6 months
- Agree to visit dental department or personal dentist for oral infectious foci eradication
- Aged over 18 years
- Affiliated with Social Security or health insurance
- Provided informed consent to participate
You will not qualify if you...
- OPT or CBCT already performed before study inclusion and available during hospitalization
- Medical contraindications to OPT or CBCT imaging
- No microbiologic identification of IE responsible microorganism
- Pregnant or breastfeeding women
- Unable to give informed consent (under guardianship, trusteeship, or legal protection)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
CHU Bordeaux - Site Pellegrin
Bordeaux, France
Actively Recruiting
2
CHU Clermont-Ferrand
Clermont-Ferrand, France
Actively Recruiting
3
CHU Grenoble
Grenoble, France
Actively Recruiting
4
HCL
Lyon, France
Actively Recruiting
5
APHM
Marseille, France
Actively Recruiting
6
CHRU Nancy
Nancy, France
Actively Recruiting
7
CHU Nantes
Nantes, France
Actively Recruiting
8
AP-HP - Site Bretonneau
Paris, France
Actively Recruiting
9
CHU Toulouse
Toulouse, France
Actively Recruiting
10
CHRU Tours
Tours, France
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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