Actively Recruiting
CBD for Knee Osteoarthritis
Led by University of Florida · Updated on 2025-09-17
30
Participants Needed
1
Research Sites
132 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population. Many physically active Americans have reported pain-relieving effects of cannabidiol (CBD) that can reduce or eliminate use of nonsteroidal anti-inflammatory drugs (NSAIDs) for activity-related pain with minimal to no side effects. Long-term use of over-the-counter medications, including NSAIDs, can pose a significant health risk, and therefore clinical research on the safety and efficacy of CBD is needed.
CONDITIONS
Official Title
CBD for Knee Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Established clinical diagnosis of knee osteoarthritis (KOA)
- Moderate to severe knee pain (4 or higher out of 10) with physical activity in one or both knees
- Age between 40 and 75 years
You will not qualify if you...
- Pregnant or lactating
- Current use of cannabis (THC and/or CBD)
- Any medical condition that could affect safety as judged by investigators
- Major surgery within 3 months prior to recruitment or planned orthopedic surgery during the study
- Exposure to another investigational drug within 3 months prior to screening
- Body Mass Index (BMI) of 45 or higher
- Current use of enzyme-modifying drugs including strong CYP enzyme inhibitors or inducers
- History of suicidal thoughts or self-harm behavior
- History of seizure disorder or traumatic brain injury
- History of liver or kidney disease
- History of cardiovascular diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sports Medicine Research Laboratory
Gainesville, Florida, United States, 32601
Actively Recruiting
Research Team
P
Paul A. Borsa, PhD
CONTACT
J
John W Stauffer, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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