Study of Epidiolex CBD to Help Reduce Pain After Rotator Cuff Shoulder Surgery

What this Trial Is About

Researchers are evaluating whether Epidiolex cannabidiol can help reduce pain when added to standard pain medications after orthopedic shoulder surgery, specifically rotator cuff repair. This randomized, triple-blind study aims to identify safe dosage levels and any side effects occurring after surgery. The trial compares Epidiolex to a placebo solution to see if it lowers postoperative pain effectively. Participants will be randomly assigned based on their surgery type to receive either 150mg of Epidiolex or a 150mg placebo oral solution twice daily with food for 14 days starting on the day of surgery. During this period, participants will track their pain and medication use daily in a provided pain diary. Researchers will call participants weekly to check on their diary and medication compliance and monitor any adverse events. Participants will complete two short surveys before and two weeks after surgery about sleep, activity, and pain. Blood tests, including liver panels, will be done after surgery and at the postoperative visit 11 to 17 days later. Safety monitoring calls will assess any side effects or concerns. The studys primary outcome is pain recorded in the pain journal over two weeks, with additional assessments of pain disability, general activity, anxiety, and sleep quality.

CBD for Pain Following Orthopedic Shoulder Surgery