Actively Recruiting
CBG/CBD Oil for Chemotherapy-Induced Peripheral Neuropathy
Led by Milton S. Hershey Medical Center · Updated on 2026-05-11
12
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if a commercially available cannabigerol (CBG)/cannabidiol (CBD) oil is safe, feasible to use, and can help reduce symptoms of chemotherapy-induced peripheral neuropathy (CIPN) in adults who have completed platinum-based chemotherapy for gastrointestinal cancers. The main questions it aims to answer are: Is CBG/CBD oil safe and well-tolerated over a 12-week treatment period? Can participants with CIPN use CBG/CBD oil consistently as part of their care? Does CBG/CBD oil help reduce pain, numbness, or other symptoms of CIPN? Participants will: Take CBG/CBD oil under the tongue (sublingually) twice daily for 12 weeks Complete regular symptom assessments and functional tests during study visits Provide blood samples for cannabinoid and metabolite level testing
CONDITIONS
Official Title
CBG/CBD Oil for Chemotherapy-Induced Peripheral Neuropathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 21 years or older
- Patients with grade 1 or greater chemotherapy-induced peripheral neuropathy symptoms lasting more than 2 weeks
- Completion of platinum-based chemotherapy for specified gastrointestinal cancers within the past 2 years
- Discontinuation of any CIPN treatments at least 2 weeks before joining the study
- Negative pregnancy test for women of childbearing potential before starting treatment
- Agreement to use effective birth control or abstain from heterosexual activity during the study and for 1 month after
- Patients must be from Penn State Health
You will not qualify if you...
- Patients under 21 years old
- History of neuropathy before chemotherapy
- Pregnant or nursing women
- Uncontrolled high blood pressure or low blood pressure
- History of stroke or heart attack
- Participation in another investigational drug study within 30 days
- Elevated liver enzymes (AST/ALT) more than 3 times normal in the past year
- Suicidal thoughts or uncontrolled depression in the past year
- Known allergies to CBG/CBD hemp extract or coconut oil
- Current systemic anti-cancer therapies
- Use of certain medications affecting liver enzymes or drug metabolism without safe monitoring
- Use of other hepatotoxic drugs unless approved by study investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Penn State Cancer Institute
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
Research Team
C
Crystal Sowers
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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