Actively Recruiting
CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT
Led by Children's Hospital of Philadelphia · Updated on 2026-02-20
50
Participants Needed
1
Research Sites
465 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The major morbidities of allogeneic hematopoietic stem cell transplant with non-human leukocyte antigen (HLA) matched siblings are graft vs host disease (GVHD) and life threatening infections. T depletion of the donor hematopoietic stem cell graft is effective in preventing GVHD, but immune reconstitution is slow, increasing the risk of infections. An addback of donor CD45RA (naive T cells) depleted cells may improve immune reconstitution and help decrease the risk of infections.
CONDITIONS
Official Title
CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients younger than 25 years.
- First allogeneic hematopoietic stem cell transplant only.
- Diagnosis of acute leukemias at high risk for relapse or related hematologic malignancies including acute myeloid leukemia, myelodysplastic syndromes, acute lymphoblastic leukemia, mixed lineage or bi-phenotypic leukemia, lymphoblastic lymphoma, Burkitt lymphoma, or juvenile myelomonocytic leukemia.
- Evaluation of organ and infectious status according to bone marrow transplant standard procedures.
- Signed consent by parent/guardian or patient if older than 18 years.
You will not qualify if you...
- Patients who do not meet institutional disease, organ, or infection criteria.
- No suitable donor available for mobilized peripheral stem cells.
- Patients with genetic disorders such as Fanconi anemia, Kostmann syndrome, dyskeratosis congenita, or other DNA repair defects.
- Patients with Hodgkin lymphoma or lymphoma types other than Burkitt or lymphoblastic lymphoma.
- Pregnant participants.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
M
Megan Atkinson
CONTACT
P
Patricia Hankins, BSN, RN, CCRC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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