Actively Recruiting
Celecoxib for ENT Pain Management
Led by University of Wisconsin, Madison · Updated on 2025-12-03
84
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to find out whether pain can be managed after an operation with celecoxib instead of oxycodone. The main question it aims to answer is if use of celecoxib plus Tylenol reduces the need for oxycodone. Researchers will compare the combination of celecoxib and Tylenol to a placebo to find out whether celecoxib works to manage pain. Participants will: * Take celecoxib, or a placebo, plus Tylenol with opioids as needed * Keep a diary of their pain between visits * Complete questionnaires
CONDITIONS
Official Title
Celecoxib for ENT Pain Management
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to understand and willing to sign informed consent
- Willing to comply with all study procedures and be available for the duration
- Ability to take oral medication
- Undergoing superficial parotidectomy
- At least 18 years of age
- Adequate organ function as shown by standard lab tests (blood count and chemistry)
You will not qualify if you...
- History of contraindications to NSAIDs, including severe heart failure, recent coronary artery bypass graft within 14 days, arrhythmias, significant coronary artery disease, cardiomyopathy, severe liver impairment, peptic ulcer disease or gastrointestinal bleeding
- Use of anticoagulation other than prophylactic aspirin
- History of uncontrolled high blood pressure or stroke
- Allergy to celecoxib or sulfa drugs
- Concurrent use of cytochrome CYP2C9 potentiators or inhibitors
- Use of investigational drugs, biologics, or devices within 30 days prior to randomization
- Pregnancy, breastfeeding, or planning pregnancy during the study
- Other reasons making the participant unsuitable at investigator's discretion
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Wisconsin
Madison, Wisconsin, United States, 53702
Actively Recruiting
Research Team
H
Hayley Mann, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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