Actively Recruiting
Cellular Immunity, Neuroendocrine, and Inflammatory Factors for Clinical Prognosis in Acute Coronary Syndrome
Led by Hospital de Clinicas José de San Martín · Updated on 2024-07-22
150
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
Sponsors
H
Hospital de Clinicas José de San Martín
Lead Sponsor
U
University of Buenos Aires
Collaborating Sponsor
AI-Summary
What this Trial Is About
In acute coronary syndrome (ACS), there is an increase in cortisol levels, as an expression of the stress response, and C-reactive protein, as an expression of the inflammatory response, which are in turn associated with changes in the components of cellular immunity, and ultimately are predictors of clinical events. The objective of this study is to demonstrate that, within the frame of reference of ACS, beyond the thrombotic phenomenon that leads to ischemia and myocardial necrosis, there is an activation of an inflammatory and stress response, evidenced by an elevation of CRP and cortisol, respectively, and sequentially modifications in the components of cellular immunity in peripheral blood that convey prognostic value during hospitalization and after discharge. A prospective, observational, analytical, unicentric study of consecutive patients with ACS, with telephone follow-up to 6 months, will be carried out. For 2 years, all eligible patients admitted with a diagnosis of ACS to the Coronary Care Unit of the Hospital de Clínicas José de San Martín in Buenos Aires will be registered consecutively.
CONDITIONS
Official Title
Cellular Immunity, Neuroendocrine, and Inflammatory Factors for Clinical Prognosis in Acute Coronary Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 21 years of age and admitted with a diagnosis of Acute Coronary Syndrome (ACS)
- Agree to participate by giving informed consent
You will not qualify if you...
- Diagnosis of chronic cancer or inflammatory disease
- Diagnosis of allergic disease, parasitic disease, asthma, or hypereosinophilic syndrome
- Severe valvular heart disease
- Acute myocardial infarction in the previous month
- Chronic corticosteroid treatment
- Creatinine clearance less than 30% by MDRD method
- Severe liver failure
- Pregnant women
- Known illness limiting life expectancy to 6 months
- Unable or unwilling to consent to participate
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hospital de Clinicas Jose de San Martin
Buenos Aires, Argentina
Actively Recruiting
Research Team
D
Diego Costa, MD, MSc.
CONTACT
S
Sandra P Sweiszkowski, MD, MSc.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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