Actively Recruiting
Cellular and Molecular Biomarkers in Patients With Lichen Planus
Led by Institut Pasteur · Updated on 2025-07-01
70
Participants Needed
6
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Lichen planus (LP) is a chronic inflammatory disease of unknown aetiology, affecting the skin and mucous membranes, characterised by a CD8+ cytotoxic T-cell infiltrate, associated with epithelial cell death and disruption of the basement membrane zone. In previous work, T cell antigen receptor (TCR) repertoire studies were performed. In all patients tested, whether with erosive or non-erosive LP, unique nucleotide sequences, called clonotypes, have been identified. They appear during the process of TCR gene rearrangement. These clonotypes are specific for human papillomavirus (HPV) in blood and lesions, suggesting antigenic stimulation of these clonotypes by a viral epitope of HPV, which crosses with an epitope on keratinocytes. The diagnosis of LP is made on the basis of clinical and histological criteria, but in some patients and in some anatomical locations, the diagnosis is difficult to make and LP may be confused with other skin conditions.
CONDITIONS
Official Title
Cellular and Molecular Biomarkers in Patients With Lichen Planus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subject diagnosed at the time of disease onset or during a progressive episode without systemic treatment or after stopping immunomodulatory or immunosuppressive treatment
- Ability to provide written consent
- Understands spoken and written French
- Affiliated with French social security or similar systems
You will not qualify if you...
- Dermatosis only located in the skin folds or on the face due to biopsy scarring risk
AI-Screening
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Trial Site Locations
Total: 6 locations
1
CHU de Besançon
Besançon, France, 25030
Actively Recruiting
2
CHU Paris Seine-Saint-Denis- Hôpital Avicenne
Bobigny, France
Actively Recruiting
3
Centre Medical de l'Institut Pasteur
Paris, France, 75015
Actively Recruiting
4
Hôpital Saint-Louis
Paris, France
Actively Recruiting
5
Hôpital Robert Debré, CHU de Reims
Reims, France, 51092
Actively Recruiting
6
CHU de Rouen
Rouen, France
Actively Recruiting
Research Team
M
Marie-Lise Gougeon
CONTACT
S
Sandrine Fernandes Pellerin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
7
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