Actively Recruiting
Central Haemodynamics and Pacing for AV Block
Led by University of Tartu · Updated on 2026-03-09
124
Participants Needed
2
Research Sites
109 weeks
Total Duration
On this page
Sponsors
U
University of Tartu
Lead Sponsor
N
North Estonia Medical Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.
CONDITIONS
Official Title
Central Haemodynamics and Pacing for AV Block
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-80 years
- Diagnosis of atrioventricular block
- Expected survival more than 1 year
You will not qualify if you...
- Left ventricular ejection fraction less than 45%
- Expected ventricular pacing burden less than 20%
- Inter-arm systolic blood pressure difference greater than 15 mmHg
- Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days
- Secondary hypertension
- Orthostatic hypotension
- Clinically significant valvular heart disease
- Congenital heart disease
- Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed
- Pregnancy or breastfeeding
- Withdrawal of consent by the subject
- Loss of contact during the study
AI-Screening
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Trial Site Locations
Total: 2 locations
1
North Estonia Medical Centre
Tallinn, Harju, Estonia, 13419
Actively Recruiting
2
Tartu University Hospital
Tartu, Tartu, Estonia, 50406
Actively Recruiting
Research Team
S
Silver Heinsar, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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