Study Comparing Two Pacemaker Pacing Methods for Atrioventricular Block and Their Effects on Heart Function and Quality of Life

What this Trial Is About

Researchers are comparing two pacing methods for patients with atrioventricular block who need a permanent pacemaker. This study evaluates conduction system pacing left bundle branch area pacing against standard right ventricular pacing to understand their effects on heart function, blood flow, and quality of life over a 12-month period. It involves 124 patients from two Estonian hospitals and aims to measure central systolic arterial pressure as the main outcome. Participants will receive either a pacemaker implanted with a right ventricular lead or a conduction system lead placed in the left bundle branch area. This single-blind, randomized study will monitor patients over one year to assess differences between these two device-based pacing strategies. The main focus is on central blood pressure one year after implantation, with additional evaluations of arterial stiffness, heart ultrasound results, electrical heart activity patterns, and quality of life. Throughout the study, patients will undergo clinical assessments including blood pressure measurements, echocardiography, and pulse wave analysis to monitor heart and vascular function. Researchers will also evaluate quality of life scores. The study carefully tracks safety and device function during the one-year follow-up. The total participation period aligns with the 12-month post-implantation monitoring phase.

Central Haemodynamics and Pacing for AV Block