Actively Recruiting
Central micrOperimetry and Radial OCT Evaluation in Geographic Atrophy (CORE-GA): a Prospective Pilot Study
Led by University of California, San Francisco · Updated on 2026-04-29
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating two imaging methods, central microperimetry and radial Optical Coherence Tomography (OCT), in patients with Geographic Atrophy (GA) or those at risk of developing this condition. The goal is to see if these methods can measure the progression of GA toward the foveal center, the key area of the retina responsible for sharp, detailed vision. The study observes several groups: patients with age-related macular degeneration (AMD) who have non-central GA not involving the fovea, those with intermediate AMD, and patients with non-central GA who are either currently receiving treatment or about to start treatment. Participants undergo high-resolution retinal imaging with OCT and functional testing with microperimetry to map retinal sensitivity. Participants will be monitored over one year with periodic imaging and sensitivity tests to track GA progression and changes in macular sensitivity. The main outcome measured is the rate of GA progression in one year, with secondary outcomes focusing on changes in retinal function over time. The study spans from June 2025 to June 2027 and does not involve investigational treatments but rather observes disease progression using advanced diagnostic tests.
CONDITIONS
Brief Title
Central micrOperimetry and Radial OCT Evaluation in Geographic Atrophy (CORE-GA): a Prospective Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects must be 55 years of age or older
- Subjects in the "Intermediate AMD Observation Arm" must have intermediate age-related macular degeneration in one eye
- Subjects in the "GA Observation Arm", "GA Continuing Treatment Arm", and "GA Treatment Arm" must have non-central geographic atrophy that does not involve the center point of the fovea
- Subjects must have at least 1% geographic atrophy in the central 1 mm zone
You will not qualify if you...
- Subjects with central involvement of geographic atrophy involving the foveal center point
- Subjects with a baseline size of geographic atrophy greater than 17.5 mm2
- Pregnant women
- Adults who cannot consent for themselves
- Subjects who use alcohol in excess, defined as binge drinking on 5 or more days in the past month
- Evidence of retinal atrophy due to causes other than atrophic age-related macular degeneration
- Subjects who had anti-VEGF injections or active choroidal neovascularization in the study eye during the last 12 months
- Subjects with ocular disorders that may affect study outcomes, including non-proliferative diabetic retinopathy with 10 or more hemorrhages or microaneurysms, active proliferative diabetic retinopathy, branch or central retinal vein or artery occlusion, macular hole, pathologic myopia, uveitis, pseudovitelliform maculopathy, or intraoperative surgery within 90 days prior to enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 year
Participants undergo diagnostic tests including optical coherence tomography and microperimetry to evaluate retinal structure and sensitivity.
Multiple visits over 1 year for imaging and functional testing
Duration - 1 year
Participants are monitored over time to assess progression of geographic atrophy and changes in macular sensitivity.
Follow-up visits for up to 1 year
Trial Site Locations
Total: 1 location
1
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
J
Jay M Stewart, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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