Evaluation of Central Microperimetry and Radial OCT Imaging in Patients Aged 55 and Older with Geographic Atrophy or Intermediate Age-Related Macular Degeneration

What this Trial Is About

Researchers are evaluating two imaging methods, central microperimetry and radial Optical Coherence Tomography OCT, in patients with Geographic Atrophy GA or those at risk of developing this condition. The goal is to see if these methods can measure the progression of GA toward the foveal center, the key area of the retina responsible for sharp, detailed vision. The study observes several groups patients with age-related macular degeneration AMD who have non-central GA not involving the fovea, those with intermediate AMD, and patients with non-central GA who are either currently receiving treatment or about to start treatment. Participants undergo high-resolution retinal imaging with OCT and functional testing with microperimetry to map retinal sensitivity. Participants will be monitored over one year with periodic imaging and sensitivity tests to track GA progression and changes in macular sensitivity. The main outcome measured is the rate of GA progression in one year, with secondary outcomes focusing on changes in retinal function over time. The study spans from June 2025 to June 2027 and does not involve investigational treatments but rather observes disease progression using advanced diagnostic tests.

Central micrOperimetry and Radial OCT Evaluation in Geographic Atrophy (CORE-GA): a Prospective Pilot Study