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Study on the Central Motor Regulation Mechanism in Adolescent Idiopathic Scoliosis (AIS) Patients Based on HD-sEMG, EEG, and Neuromuscular Coupling Analysis
Led by The First Affiliated Hospital of Zhejiang Chinese Medical University · Updated on 2025-01-03
40
Participants Needed
1
Research Sites
78 weeks
Total Duration
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AI-Summary
What this Trial Is About
Researchers are studying the central motor regulation mechanism in patients with Adolescent Idiopathic Scoliosis (AIS) aged 10 to 18 years. They aim to understand how spinal manipulation affects motor control by evaluating muscle function and trunk stability using clinical outcome measures, high-density electromyography (HD-EMG), and the Pro-Kin balance system. The study also investigates how the central motor network responds to spinal manipulation by analyzing synchronized brain and muscle electrical signals with advanced neuromuscular synchronization and coupling methods. Participants receive standardized spinal manipulation treatment called Tuina (Massage) Therapy, which involves correcting abnormal joint alignment, muscle function, and restoring joint stability and sensorimotor control. The therapy lasts 20-25 minutes per session and is applied twice a week for 12 weeks. The study compares AIS patients to a healthy control group to clarify the effectiveness of spinal manipulation on motor control in AIS. Throughout the study, participants will undergo evaluations before treatment and at 4 and 12 weeks after treatment using HD-EMG and the Pro-Kin balance system to assess paraspinal muscle function and trunk stability. Researchers analyze brain and muscle electrical signals to understand motor control characteristics. The study includes monitoring of clinical outcomes and motor network response, with total participation lasting at least 12 weeks and follow-up assessments at specified intervals.
CONDITIONS
Brief Title
Central Motor Mechanisms in AIS Via HD-sEMG, EEG and Neuromuscular Coupling Analysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 10 to 18 years
- Risser sign grade 0-3
- Cobb angle between 10° and 40°
- No prior treatment for scoliosis
- Female patients within 1 year after menarche or before menstruation
- Patient's guardian signs informed consent form
You will not qualify if you...
- Patients not meeting AIS diagnostic criteria or inclusion criteria
- Severe cardiovascular, cerebrovascular, liver, kidney, hematopoietic diseases, or mental illnesses
- Thrombocytopenia, coagulation disorders, or bleeding tendencies
- Patients afraid of or intolerant to the treatment
- Patients who have received other treatments affecting study outcomes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 12 weeks
Participants receive Tuina (Massage) Therapy involving joint realignment, muscle function correction, and sensorimotor control restoration. Treatments last 20-25 minutes each, twice a week for 12 weeks.
Twice-weekly visits for 12 weeks
Trial Site Locations
Total: 1 location
1
the First Affiliated Hospital of Zhejiang Chinese Medical University
Hangzhou, China
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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