Actively Recruiting
Study on Central Motor Regulation in Adolescent Idiopathic Scoliosis Using HD-sEMG, EEG, and Neuromuscular Coupling Analysis
Led by The First Affiliated Hospital of Zhejiang Chinese Medical University · Updated on 2025-01-03
40
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of spinal manipulation on motor control in patients with Adolescent Idiopathic Scoliosis (AIS). The study aims to clarify the role of spinal manipulation in regulating motor control by assessing clinical outcomes, paraspinal muscle function using high-density electromyography (HD-EMG), and trunk stability with the Pro-Kin balance system. Additionally, the study explores the response of the central motor network to spinal manipulation by analyzing synchronized brain and muscle electrical signals through combined HD-sEMG and EEG technology. Participants receive standardized Tuina (massage) therapy, which involves correcting abnormal joint alignment, muscle function, and joint stability through manipulative realignment and muscle stretching and strengthening exercises. The therapy also includes sensorimotor control restoration by applying movement disturbances to enhance proprioception and motor memory. Each treatment session lasts 20 to 25 minutes, is performed twice weekly, and continues for a total of 12 weeks. Throughout the study, participants undergo assessments including HD-EMG before treatment and at 4 and 12 weeks post-treatment to measure paraspinal muscle function. Researchers evaluate motor control by analyzing neuromuscular synchronization and coupling between brain and muscle signals. The study monitors treatment adherence, motor control effects, and safety. Participation involves outpatient or inpatient visits over the 12-week treatment period.
CONDITIONS
Official Title
Central Motor Mechanisms in AIS Via HD-sEMG, EEG and Neuromuscular Coupling Analysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 10 years and older
- Risser sign grade 0 to 3
- Cobb angle between 10° and 40°
- No prior treatment for scoliosis
- Female patients within 1 year after menarche or before menstruation
- Patient's guardian has signed informed consent form for treatment
You will not qualify if you...
- Not meeting the diagnostic criteria for AIS or the inclusion criteria
- Severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney, or hematopoietic disorders, or mental illnesses
- Thrombocytopenia, coagulation disorders, or bleeding tendency
- Fear of treatment and inability to tolerate it
- Previous treatments that may affect study outcome measures
AI-Screening
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Trial Site Locations
Total: 1 location
1
the First Affiliated Hospital of Zhejiang Chinese Medical University
Hangzhou, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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