Actively Recruiting
Cerclage Plus Progesterone vs Progesterone Alone in Twin Short Cervix
Led by National Hospital of Obstetrics and Gynecology · Updated on 2026-04-24
260
Participants Needed
6
Research Sites
163 weeks
Total Duration
On this page
Sponsors
N
National Hospital of Obstetrics and Gynecology
Lead Sponsor
Q
Quang Ninh Obstetrics and Pediatrics Hospital, Quang Ninh, Vietnam
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to compare the effectiveness of cervical cerclage combined with progesterone versus progesterone alone in preventing preterm birth among women with twin pregnancies and a short cervix (cervical length ≤ 30 mm). Participants will be randomly allocated to either the intervention group (cerclage plus progesterone) or the control group (progesterone alone).
CONDITIONS
Official Title
Cerclage Plus Progesterone vs Progesterone Alone in Twin Short Cervix
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Maternal age 18 years or older
- Pregnant with twins
- Asymptomatic short cervix measuring 30 mm or less at routine ultrasound
- Gestational age between 16 weeks 0 days and 24 weeks 0 days
You will not qualify if you...
- Twin pregnancy where one or both babies have major structural or congenital abnormalities likely to affect neonatal outcomes
- Monochorionic monoamniotic twin pregnancy
- Monochorionic twin pregnancy with twin-to-twin transfusion syndrome before or at study entry
- History of two or more late miscarriages or preterm births indicating need for vaginal cerclage
- Cervical dilation detected by ultrasound or physical exam
- Symptoms of preterm labor at cervix measurement (regular contractions, premature rupture of membranes, recurrent bleeding)
- Fever of 38°C (100.4°F) or higher
- Placenta previa or vasa previa
- Uterine malformations such as unicornuate uterus, bicornuate uterus, uterine septum, or fibroids
- Severe maternal health conditions like heart failure, chronic kidney disease, or systemic lupus erythematosus
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Bac Ninh 1 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam
Bac Ninh, Vietnam, 220000
Not Yet Recruiting
2
Bac Ninh 2 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam
Bac Ninh, Vietnam, 220000
Not Yet Recruiting
3
National Hospital of Obstetrics and Gynecology
Hanoi, Vietnam, 100000
Actively Recruiting
4
Hung Yen Obstetrics and Pediatrics Hospital, Hung Yen, Vietnam
Hung Yen, Vietnam, 160000
Not Yet Recruiting
5
Ninh Binh Obstetrics and Pediatrics Hospital, Ninh Binh, Vietnam
Ninh Binh, Vietnam, 430000
Not Yet Recruiting
6
Quang Ninh Obstetrics and Pediatrics Hospital, Quang Ninh, Vietnam
Quang Ninh, Vietnam, 200000
Not Yet Recruiting
Research Team
T
Thu Ha T Nguyen, Assoc. Prof
CONTACT
V
Viet C Dang, MD, MsC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here