Actively Recruiting
Cerebellar Deep Brain Stimulation or VNS for Chronic Post-stroke Motor Rehabilitation
Led by Qilu Hospital of Shandong University · Updated on 2025-04-17
100
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts.In this open-label, randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with bilateral or unilateral stimulation. Vagus nerve stimulation was also conducted for motor function after ischaemic Stroke.We hypothesized that cerebellar stimulation was superior to vagus stimulation as the motor rehabilitation after stroke benefits from both side of cerebellum.
CONDITIONS
Official Title
Cerebellar Deep Brain Stimulation or VNS for Chronic Post-stroke Motor Rehabilitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Suffered a first-time, unilateral ischemic stroke in the middle cerebral artery territory 12 to 36 months before surgery, sparing the diencephalon and basal ganglia
- Persistent moderate-to-severe upper-extremity hemiparesis with an FM-UE score of 42 or less
- Have sufficient upper-extremity motor ability to engage in rehabilitation (score of 1 or more on FM-UE elbow flexion, elbow extension, or finger mass flexion or extension)
You will not qualify if you...
- Excessive spasticity or contracture of the upper-extremity muscles (Modified Ashworth Scale = 4)
- Severe cognitive impairment with Mini Mental State Examination score less than 24
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chao Zhang
Jinan, Shandong, China, 250100
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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