Actively Recruiting
Cerebellar Involvement in Cognitive Sequencing
Led by Johns Hopkins University · Updated on 2026-01-12
50
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Although there is increasing recognition that the cerebellum is involved in cognition as well as motor function, the manner in which the cerebellum contributes to cognition is uncertain. One theory that might account for both motor and cognitive contributions of the cerebellum is that the cerebellum is involved in sequencing of relevant events or stimuli. Previous experiments have suggested that disruption of the cerebellum impairs the prediction of the next event in a sequence. The present experiment will examine the impact of cerebellar stimulation on brain activation during the performance of both sequence-demanding and non-sequence-demanding tasks.
CONDITIONS
Official Title
Cerebellar Involvement in Cognitive Sequencing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-50
- Educational attainment of at least 8 years
- Capable of giving informed consent
- Fluent speaker of English by self-report
- Right handed
You will not qualify if you...
- Illicit drug use within 30 days of MRI scanning
- Neurological or systemic disorder causing dementia or cognitive dysfunction
- History of Axis I psychiatric disorder including substance use disorder
- History of definite stroke
- Focal lesion on MRI exam
- Uncorrected visual deficits by self-report
- Contraindications for MRI scanning
- Use of anxiolytic, antidepressant, neuroleptic, or sedative medication
- Additional exclusion criteria for TMS neuromodulation, including history of seizure or family history of epilepsy, heart disease, intracardiac lines, increased intracranial pressure, history of head trauma, and history of respiratory disease
AI-Screening
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Trial Site Locations
Total: 1 location
1
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21205
Actively Recruiting
Research Team
J
John E Desmond, Ph.D.
CONTACT
J
JoAnna Mathena, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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