Actively Recruiting
Cerebellar Transcranial Direct Current Stimulation (tDCS) in Patients With Isolated Cervical Dystonia (CD)
Led by Universitätsklinikum Hamburg-Eppendorf · Updated on 2025-06-11
20
Participants Needed
1
Research Sites
67 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cervical dystonia (CD) is a movement disorder characterized by involuntary muscle contractions of the neck, leading to abnormal head postures and movement, pain and impaired motor function. Current treatments for CD, such as botulinum toxin injections and physical therapy, may not always provide sufficient relief of symptoms and may fail to offer long-term benefits for patients. As a result, new therapeutic approaches are needed. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that modulates neuronal activity. Recent neurophysiological studies suggest that cerebellar tDCS (ctDCS), in particular, could be beneficial in modulating the activity of the sensorimotor network in CD. This clinical trial aims to investigate the effects of ctDCS on the excitability of the sensorimotor network and motor symptom severity in CD patients. Applying transcranial magnetic stimulation (TMS) we will evaluate the effects of anodal, cathodal and sham ctDCS to improve the understanding of the neurophysiological mechanisms underlying CD and the potential therapeutic role of ctDCS.
CONDITIONS
Official Title
Cerebellar Transcranial Direct Current Stimulation (tDCS) in Patients With Isolated Cervical Dystonia (CD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of isolated cervical dystonia
- Written informed consent by the patient
You will not qualify if you...
- History of other neurological disorders other than CD
- Secondary dystonia
- Severe head tremor
- Intake of centrally acting medication
- Contraindications to TMS, such as metallic implants, pregnancy and history of seizures
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Neurology, University Medical Center Hamburg-Eppendorf
Hamburg, Germany
Actively Recruiting
Research Team
S
Simone Zittel, Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
3
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