Actively Recruiting
Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury
Led by University of Texas Southwestern Medical Center · Updated on 2025-07-01
130
Participants Needed
3
Research Sites
247 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
A
Albert Einstein College of Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (\< 1 week) cerebrovascular injury and its recovery within the first year postinjury measured by cerebral autoregulation and brain perfusion are associated with cognitive outcome at 12 months after msTBI. The results from this study will improve our understanding of cerebrovascular contributions to cognitive decline related to TBI and provide critical data to inform the development of strategies based on vascular mechanisms to improve cognition and prevent neurodegeneration after msTBI.
CONDITIONS
Official Title
Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Documented moderate to severe traumatic brain injury (TBI) according to ACRM criteria
- Moderate to severe TBI defined by Glasgow Coma Scale less than 13, loss of consciousness over 30 minutes, posttraumatic amnesia over 24 hours, or abnormal brain imaging
- Age between 18 and 80 years old
- Injury occurred within 1 week prior to enrollment
- Had an acute brain CT scan for clinical care
- Admitted to hospital for TBI
- Adequate vision and hearing for testing
- Fluent in English or Spanish
- Ability of patient or legal representative to give informed consent
You will not qualify if you...
- Age younger than 18 or older than 80 years
- Severe multiple injuries that interfere with follow-up or assessments
- Major mental health disorders like schizophrenia, bipolar disorder, or severe depression with active suicidal thoughts
- Major neurological diseases such as stroke, dementia, or brain tumor impairing cognition or assessment
- Pre-existing conditions interfering with follow-up like active substance abuse, HIV/AIDS, end-stage cancers, learning disabilities, or developmental disorders
- Patients on psychiatric hold
- Prisoners or patients in custody
- Pregnancy in female participants
- Low likelihood of completing follow-up (e.g., living out of state, homeless, or lacking reliable contacts)
- Currently enrolled in another interventional trial
- Penetrating traumatic brain injury
- Spinal cord injury with severe impairment (ASIA score C or worse)
- Contraindications to MRI scanning
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Texas Health Presbyterian Hospital
Dallas, Texas, United States, 75231
Actively Recruiting
2
Parkland Health and Hospital System
Dallas, Texas, United States, 75235
Actively Recruiting
3
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
K
Kan Ding, MD
CONTACT
J
Jill Morales, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here