Brain Blood Pressure Monitoring During Major Non-Cardiac Surgery in Adults 60 and Older Relation to Postoperative Brain Health and Delirium

What this Trial Is About

Researchers are studying patients over 60 years old undergoing major non-cardiac surgery to find the best blood pressure level to maintain during surgery for optimal brain health. This observational study aims to determine if non-invasive monitors measuring brain electrical activity EEG and blood oxygen levels cerebral oximetry can help tailor blood pressure for each individual and understand how much this optimal level differs between patients. Participants will have EEG and cerebral oximetry monitoring stickers placed on their foreheads before surgery, which will collect data throughout the surgery and up to 24 hours afterward or until extubation. These monitors will be connected to specialized equipment that records brain and blood pressure data in real-time without affecting medical care. The study includes assessments before surgery, during surgery, and after surgery, including cognitive and delirium testing using standardized tools like the Montreal Cognitive Assessment MoCA and Confusion Assessment Method CAM. During the study, participants will complete questionnaires about their brain health at enrollment and daily after surgery. They will undergo baseline cognitive testing before surgery, continuous brain monitoring during surgery, and daily cognitive and delirium assessments during hospitalization. Follow-up assessments by phone will occur at one month and six months after surgery. Researchers will also collect medical data such as medications, pain scores, and vital signs to analyze alongside cognitive outcomes. The primary focus is on measuring cerebral autoregulation and brain function related to blood pressure during and after surgery.

CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State