Study of Cerebral Autoregulation and Stroke Recurrence in Adults with Symptomatic Cerebral Artery Stenosis

What this Trial Is About

Researchers are studying patients with symptomatic cerebral atherosclerotic stenosis sCAS, a condition linked to 33-50% of ischemic strokes in China and a high risk of stroke recurrence. The study aims to explore how cerebral autoregulation CA, the brains ability to maintain stable blood flow despite blood pressure changes, relates to stroke recurrence and to identify CA parameter thresholds that may predict recurrence. This is a multi-center prospective observational study enrolling 850 patients. The study involves measuring cerebral autoregulation using transcranial Doppler combined with a servo-controlled plethysmograph at two time points within 0-3 days and 10-30 days after an ischemic cerebrovascular event such as a stroke or transient ischemic attack. Clinical data, brain imaging, biochemical tests, and follow-up information will be collected and recorded. No experimental drug or treatment is given, as this is an observational study focused on assessing CA and its relationship to stroke outcomes. Participants will undergo assessments at specified intervals, including cerebral autoregulation measurements shortly after their stroke or transient ischemic attack. Researchers will collect clinical and imaging data and follow participants for up to two years to track stroke recurrence and related outcomes. Primary outcomes include stroke recurrence rates over two years, while secondary measures include cerebral autoregulation indices, functional scores like the modified Rankin Scale mRS and Barthel score, and neurological status assessed by the NIH Stroke Scale NIHSS.

Cerebral Autoregulation in Patients With Symptomatic Cerebral Atherosclerotic Stenosis