Study of How Lowering Cerebral Blood Flow Affects Breathing During Sleep Under Normal Oxygen and Intermittent Low Oxygen Conditions in Healthy Adults

What this Trial Is About

Researchers are investigating how changes in cerebral blood flow affect breathing responses during sleep in healthy adults. The study focuses on the bodys ventilatory reactions to low oxygen hypoxia and high carbon dioxide hypercapnia levels, both under normal oxygen conditions and during intermittent low oxygen exposure. This double-blind, placebo-controlled, randomized crossover trial aims to better understand these relationships over approximately 18 months. Participants will receive a drug designed to lower cerebral blood flow or a placebo in a random order. They will sleep under two different conditions normal oxygen normoxia and intermittent low oxygen intermittent hypoxia. Each participant experiences all combinations of drugplacebo and sleep conditions, with washout periods between exposures. Blood and urine samples will be collected to measure vascular and oxidative stress biomarkers. During the study, participants undergo assessments of cerebral blood flow and ventilatory responses before, during, and after sleep. Researchers will monitor breathing stability and collect samples for reactive oxygen species and vascular biomarker analysis over about 24 months. The study includes detailed monitoring of ventilatory chemoreflexes and cerebral blood flow changes to understand ventilatory stability during sleep.

Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia