Multiomics Biobank Study for Patients with Acute Ischemic Stroke Due to Large Vessel Occlusion at Multiple Centers

What this Trial Is About

Researchers are conducting a multicenter, ambispective cohort study to collect and analyze samples and data from patients with acute ischemic stroke caused by large vessel occlusion AIS-LVO. The study aims to build a comprehensive biobank including thrombi, intracranial blood, peripheral arterial and venous blood, along with clinical, laboratory, imaging, and follow-up information. This will help explore differences in blood samples and develop a detailed multiomics profile related to stroke. Samples such as blood clots and blood from different sites undergo pathological, metabolomic, proteomic, and genomic tests for multidimensional analysis. The study collects data from five stroke centers and includes pathological and histological examination of thrombus samples for some patients. Researchers plan to use these findings to identify stroke causes, therapeutic targets, risk factors, and prognosis by creating prediction models based on the combined multiomics data. Participants provide clinical and biological samples, and their health status is monitored through clinical and imaging evaluations over time. The primary outcome measured is the number of patients experiencing futile recanalization from enrollment to three months follow-up. Secondary outcomes include stroke causes, hemorrhagic transformation within seven days, and infarct expansion at baseline. The study is observational and involves no experimental treatments, focusing on data and sample collection to advance stroke research.

Cerebral Large Vessel Occlusion Stroke Multiomics Biosample Cohort